Singular effects of PPAR agonists on nonalcoholic fatty liver disease of diet-induced obese mice

Life Sciences
Sandra Barbosa-da-SilvaCarlos Alberto Mandarim-de-Lacerda

Abstract

To assess the effects of peroxisome proliferator-activated receptor (PPAR) agonists on glucose tolerance and hepatic lipid metabolism in diet-induced obese mice. Male C57BL/6 mice received a standard chow diet (SC, 10% energy as lipids) or high-fat diet (HF, 50% energy as lipids) for 10 weeks, after which treatment was initiated, forming the groups: SC group, HF group, HF-BZ group (HF + bezafibrate, pan-PPAR agonist), HF-WY group (HF + WY-14643, PPARalpha agonist) and HF-GW group (HF + GW1929, PPARgamma agonist). Treatments lasted for four weeks. Insulin resistance and liver remodeling were evaluated by biochemical and molecular approaches. The HF and HF-GW mice were overweight. Conversely, the HF-BZ and HF-WY mice presented with body masses equal to those of the SC mice. All treatments restored insulin sensitivity and blood lipid and adiponectin levels. Hepatic steatosis was prevented in the HF-WY and HF-BZ mice as shown by the elevated mRNA levels of PPARalpha and Carnitine palmitoyl transferase-1a in both groups, which favored enhanced beta-oxidation. Marked decreases in liver triacylglycerol levels confirmed these findings. In contrast, the HF-GW mice exhibited increased PPARgamma and fatty acid translocase/CD136 mRNA level...Continue Reading

References

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Citations

Apr 14, 2016·Journal of Applied Toxicology : JAT·Yun ZhangZhenzhou Jiang
Oct 28, 2016·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Thatiany de Souza MarinhoCarlos A Mandarim-de-Lacerda
Apr 22, 2017·The Journal of Endocrinology·Caroline E Geisler, Benjamin J Renquist
Jan 19, 2017·Hormone Molecular Biology and Clinical Investigation·Thereza Cristina Lonzetti BargutCarlos Alberto Mandarim-de-Lacerda
Jan 4, 2017·International Journal of Hepatology·Antje BruckbauerMichael B Zemel
Dec 20, 2019·Naunyn-Schmiedeberg's Archives of Pharmacology·Mahitab Mohamed NageebNoha Abbas Teleb
Jul 25, 2019·Frontiers in Pharmacology·Ingrid Fleming
Jan 4, 2020·Prostaglandins & Other Lipid Mediators·Laila R B Dos Santos, Ingrid Fleming
Jan 15, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shifan TangYanfen Huang
Dec 17, 2020·International Journal of Molecular Sciences·Yukiomi NakadeMasashi Yoneda
Feb 13, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shu Yun ZhuYing Dong

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