Sink into the Epigenome: Histones as Repositories That Influence Cellular Metabolism

Trends in Endocrinology and Metabolism : TEM
Cunqi Ye, Benjamin P Tu

Abstract

Epigenetic modifications on chromatin are most commonly thought to be involved in the transcriptional regulation of gene expression. Due to their dependency on small-molecule metabolites, these modifications can relay information about cellular metabolic state to the genome for the activation or repression of particular sets of genes. In this review we discuss emerging evidence that these modifications might also have a metabolic purpose. Due to their abundance, the histones have the capacity to store substantial amounts of useful metabolites or to enable important metabolic transformations. Such metabolic functions for histones could help to explain the widespread occurrence of particular modifications that may not always be strongly correlated with transcriptional activity.

Citations

Sep 23, 2020·Nature Metabolism·Fabien FrancoPing-Chih Ho
Sep 20, 2018·Proceedings of the National Academy of Sciences of the United States of America·Zhiguang HuangBenjamin P Tu
Jul 19, 2020·Epigenetics & Chromatin·Christina DemetriadouAntonis Kirmizis
Mar 14, 2020·Nature Communications·Sabrina JabsPascale Cossart
Dec 11, 2019·British Journal of Cancer·Nikos Koundouros, George Poulogiannis
Oct 14, 2020·Nature Metabolism·Ruben BoonRaul Mostoslavsky
Dec 9, 2020·Nucleic Acids Research·Xiangle RenHaitao Li
Jul 8, 2019·Trends in Endocrinology and Metabolism : TEM·Sean L McGee, Mark Hargreaves
Dec 20, 2020·Cancers·Pasquale SaggeseClaudio Scafoglio
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Pedro VizánSergi Aranda
May 21, 2020·Cell Metabolism·C Hai LyJames G Ryall

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