PMID: 3756502Sep 3, 1986Paper

Sinoaortic denervation does not prevent differential Pavlovian conditioning of bradycardia in rabbits

Brain Research
T W JarrellN Schneiderman

Abstract

Recent findings suggest that descending projections from the amygdaloid central nucleus (ACE) to the nucleus of the solitary tract (NTS) may modulate the baroreceptor reflex and thereby facilitate the expression of the bradycardiac conditioned response (CR) in rabbits. The purpose of the present study was to examine the role of the afferent limb of the baroreceptor reflex in differential Pavlovian conditioning of bradycardia in rabbits. Animals received either aortic denervation, sinoaortic denervation or sham denervation. After recovery from surgery, animals received one differential Pavlovian conditioning session per day over the next 6 days. Sinoaortic denervation abolished the baroreceptor reflex as assessed by intravenous injections of phenylephrine. In addition, sinoaortic denervation increased baseline heart rate (HR), altered the topography of the HR unconditioned response, but did not abolish the HR orienting response or prevent the acquisition of bradycardiac CRs. The findings of the present study suggest that afferent barosensory input is necessary for the expression of the HR CR in rabbits. However, descending ACE projections may still play a role in the HR CR by directly affecting NTS neurons.

References

Dec 1, 1979·Physiology & Behavior·B S KappJ R Haselton
Jun 1, 1973·Journal of Comparative and Physiological Psychology·R D FitzgeraldJ H O'Brien
Jun 1, 1969·Journal of Comparative and Physiological Psychology·N SchneidermanE Schneiderman
Aug 1, 1971·Journal of Comparative and Physiological Psychology·D A PowellA Jacobson
Mar 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·N Alexander, M DeCuir
Aug 1, 1967·Journal of Comparative and Physiological Psychology·A YehleN Schneiderman
Apr 1, 1984·Journal of the Autonomic Nervous System·K H SchlörG Stock

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