PMID: 9435610Jan 22, 1998Paper

Sinoaortic denervation prevents postexercise reductions in arterial pressure and cardiac sympathetic tonus

The American Journal of Physiology
M P Chandler, Stephen E Dicarlo

Abstract

Arterial pressure, cardiac sympathetic tonus (ST), and heart rate (HR) are reduced after a single bout of dynamic exercise in spontaneously hypertensive rats (SHR). To test if the arterial baroreflex is required for these postexercise responses, intact (n = 9) and sinoaortic-denervated (SAD) rats (n = 5) were chronically instrumented with an arterial catheter for the measurement of arterial pressure and HR and for the infusion of cardiac autonomic antagonists. Five days after instrumentation, cardiac ST and parasympathetic tonus (PT) were determined under two experimental conditions (no exercise and postexercise). SAD rats did not alter no-exercise cardiac ST (intact 47 +/- 3 vs. SAD 50 +/- 3 beats/min); however, no-exercise PT was reduced (intact -24 +/- 2 vs. SAD -4 +/- 4 beats/min, P < 0.05). Acute exercise reduced arterial pressure (postexertional hypotension, -20 +/- 3 mmHg, P < 0.05), cardiac ST (no exercise 47 +/- 3 vs. postexercise 24 +/- 3 beats/min, P < 0.05), and PT (no exercise -24 +/- 2 vs. postexercise -11 +/- 2 beats/min, P < 0.05) in intact SHR. In contrast, SAD prevented postexercise reductions in arterial pressure and cardiac ST (no exercise 50 +/- 3 vs. postexercise 59 +/- 7 beats/min). Furthermore, SAD had n...Continue Reading

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Citations

Apr 23, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Cristiana A OgiharaMonica A Sato
Oct 17, 2015·Stress : the International Journal on the Biology of Stress·Yuan-Chang HsuYu-Min Kuo
Jul 19, 2001·Annals of the New York Academy of Sciences·S E DiCarlo, V S Bishop
Jul 13, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H L CollinsS E DiCarlo
Dec 1, 2001·Clinical and Experimental Hypertension : CHE·H L CollinsS E DiCarlo
Aug 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Heidi L LujanStephen E DiCarlo
May 26, 2010·European Journal of Applied Physiology·Thaís de Oliveira FariaJuliana Hott de Fúcio Lizardo
Jun 15, 2011·Experimental Physiology·Fernanda Luciano RodriguesRubens Fazan
Oct 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chao-Yin ChenAnn C Bonham
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Radhika KajekarAnn C Bonham
Jun 7, 2006·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Naoyoshi MinamiMasahiro Kohzuki
Mar 24, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Heidi L LujanStephen E Dicarlo

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