PMID: 9672124Jul 22, 1998Paper

Sinoaortic denervation produces sodium retention in Dahl salt-sensitive rats

Journal of the Autonomic Nervous System
Q H ChenH Kosaka

Abstract

The role of the arterial baroafferent signals in sodium (Na) homeostasis was examined in salt-sensitive rats. Sodium balances, water balances, and systolic arterial pressure (SAP) were measured for 3 weeks in sinoaortic denervated (SAD) or sham denervated (Sham) Dahl salt-sensitive (S) and salt-resistant (R) rats fed a standard-salt diet (0.4% NaCl). In R rats, there was no significant difference in Na balance, water balance, or SAP between the SAD and Sham animals. In the S rats, urinary Na excretion was suppressed in the SAD but not in the Sham animals, resulting in Na retention. SAD significantly increased SAP and mean arterial pressure. High salt challenge (8% NaCl diet) markedly increased SAP and Na and water balances in both S-SAD and S-Sham rats. However, no significant difference was found in SAP or cumulative Na and water balances between S-SAD and S-Sham rats. These results suggest that the baroafferent signals may have some role on the regulation of Na balance in salt-sensitive animals under a standard-salt condition, although a high-salt load masked the baroafferent-dependent sodium excretion.

References

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Citations

Oct 6, 1998·Journal of the Autonomic Nervous System·Q H ChenH Kosaka
Jun 6, 2016·The Journal of Physiological Sciences : JPS·Yasuhiro NishidaHidetake Yokoe
Aug 1, 2006·Journal of Hypertension·Bruce N Van VlietAllison M Leonard
Dec 20, 2018·Frontiers in Physiology·Elaine Fernanda da SilvaEduardo Colombari
Nov 22, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Kazuo SakamotoKenji Sunagawa
Dec 31, 2016·The Journal of Physiological Sciences : JPS·Ichiro ShojiYasuhiro Nishida

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