Sinomenine attenuates airway inflammation and remodeling in a mouse model of asthma

Molecular Medicine Reports
Hai-Rong BaoXiao-Li Zeng

Abstract

Asthma is an inflammatory disease that involves airway inflammation and remodeling. Sinomenine (SIN) has been demonstrated to have immunosuppressive and anti‑inflammatory properties. The aim of the present study was to investigate the inhibitory effects of SIN on airway inflammation and remodeling in an asthma mouse model and observe the effects of SIN on the transforming growth factor‑β1 (TGF‑β1)/connective tissue growth factor (CTGF) pathway and oxidative stress. Female BALB/c mice were sensitized by repetitive ovalbumin (OVA) challenge for 6 weeks in order to develop a mouse model of asthma. OVA‑sensitized animals received SIN (25, 50 and 75 mg/kg) or dexamethasone (2 mg/kg). A blank control group received saline only. The area of smooth muscle and collagen, levels of mucus secretion and inflammatory cell infiltration were evaluated 24 h subsequent to the final OVA challenge. mRNA and protein levels of TGF‑β1 and CTGF were determined by reverse transcription‑quantitative polymerase chain reaction and immunohistology, respectively. The indicators of oxidative stress were detected by spectrophotometry. SIN significantly reduced allergen‑induced increases in smooth muscle thickness, mucous gland hypertrophy, goblet cell hyperpl...Continue Reading

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Citations

Mar 3, 2020·Immunopharmacology and Immunotoxicology·Nina YinZhigang Wang
Feb 25, 2020·Oxidative Medicine and Cellular Longevity·Luiz Henrique C VasconcelosBagnólia A da Silva
Mar 26, 2021·Oxidative Medicine and Cellular Longevity·Luiz H C VasconcelosBagnólia A da Silva

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Methods Mentioned

BETA
bronchoalveolar
lavage
MDA

Software Mentioned

MetaMorph
SPSS
Pro Plus
Image

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