Sinonasal neuroendocrine carcinoma: a population-based analysis of incidence and survival

International Forum of Allergy & Rhinology
Tapan D PatelJean Anderson Eloy

Abstract

Sinonasal neuroendocrine carcinoma (SNEC) is a rare, aggressive tumor usually associated with a poor prognosis. This study analyzes the clinicopathological characteristics and survival outcomes of SNEC using population-based data. The Surveillance, Epidemiology, and End Results (SEER) database (1973 to 2011) was queried for SNEC cases. Data analyzed included patient demographics, incidence, treatment modality, and survival. A total of 201 cases of SNEC were identified. Mean age at diagnosis was 55.8 ± 15.7 years. Overall 5-year disease-specific survival (DSS) rate for SNEC was 50.8%. Five-year survival analysis for SNEC by site revealed DSS of 80.7%, 59.2%, 34.5%, and 33.0% for the sphenoid sinus, nasal cavity, maxillary sinus, and ethmoid sinus, respectively (p = 0.0014). Cox proportional hazard analysis revealed greater hazard of death for the maxillary (hazard ratio [HR] 2.14; 95% confidence interval [CI], 1.21 to 3.71; p = 0.0094) and ethmoid sinuses (HR 1.83; 95% CI, 1.05 to 3.16; p = 0.0345) when compared to the nasal cavity. Advanced stage disease (stages III to IV, 5-year DSS 40.5%, p = 0.0008) was associated with poor survival outcomes. Survival was better among those treated with surgery (with [59.4%] or without [69.0...Continue Reading

References

Jan 1, 1995·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·F M GrippC J Meijer
Aug 26, 1998·Human Pathology·B Perez-OrdonezJ P Shah
Mar 21, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Stacey E Mills
Mar 11, 2006·The Journal of Laryngology and Otology·E BabinD Dehesdin
Nov 23, 2006·The British Journal of Oral & Maxillofacial Surgery·Raúl González-GarcíaFrancisco J Díaz-González
Feb 3, 2007·Seminars in Oncology·Gregory Renner
Jan 22, 2010·Indian Journal of Pathology & Microbiology·Santosh MenonShubhada V Kane
Jul 29, 2011·Head & Neck Oncology·Anna LikhachevaAdel K El-Naggar
Nov 5, 2011·Head & Neck·Elisabeth H MitchellMichael E Kupferman
Jul 11, 2012·International Forum of Allergy & Rhinology·John W WoodRoy R Casiano

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Citations

Oct 6, 2015·The Laryngoscope·Kevin ShaiganyJean Anderson Eloy
Feb 20, 2016·International Forum of Allergy & Rhinology·Ritam GhoshJean Anderson Eloy
Sep 24, 2015·The Laryngoscope·Pariket M DubalJean Anderson Eloy
Oct 10, 2015·The Laryngoscope·Pariket M DubalJean Anderson Eloy
May 12, 2015·International Forum of Allergy & Rhinology·Joseph Jacobs
Sep 6, 2017·Advances in Therapy·Fernando LópezAlfio Ferlito
Jul 23, 2019·International Forum of Allergy & Rhinology·Eric W WangCarl H Snyderman
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lester Dr Thompson
Apr 27, 2017·Virchows Archiv : an International Journal of Pathology·Lester D R Thompson, Alessandro Franchi
Jan 2, 2021·American Journal of Otolaryngology·Khalil IssaRalph Abi Hachem
Aug 4, 2021·Journal of Neuroendocrinology·Jain PranteshAmr Mohamed

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