Sinorhizobium meliloti strain 1021 produces a low-molecular-mass capsular polysaccharide that is a homopolymer of 3-deoxy-D-manno-oct-2-ulosonic acid harboring a phospholipid anchor

Glycobiology
N FraysseV Poinsot

Abstract

Sinorhizobium meliloti strain 1021 possesses the particularity to synthesize biologically inefficient capsular polysaccharides (KPS). It has been assumed that this class of compounds is not produced in high-molecular-mass (HMM) forms, even if many genetic analyses show the existence of expression of genes involved in the biosynthesis of capsular polysaccharides. The expression of these genes that are involved in the export of a KPS throughout the membrane and in the attachment of a lipid moiety has never been related to a structurally characterized surface polysaccharide. It is now reported that S. meliloti strain 1021 produces low-molecular-mass polysaccharides (4-4.5 kDa) that are exclusively composed of beta-(2-->7)-linked 3-deoxy-d-manno-oct-2-ulopyranosonic acid (Kdo) residues. These compounds are considered precursor molecules of HMM KPS, whose biosynthesis is arrested in the case of S. meliloti strain 1021. For the first time, the phospholipid anchor of a rhizobial KPS has been found, and its structure could be partially identified-namely, a phosphoglycerol moiety bearing a hydroxy-octacosanoic acid. When compared to other rhizobial KPS (composed of dimeric hexose-Kdo-like sugar repeating units), the Kdo homopolymer desc...Continue Reading

Citations

Apr 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lisa M WillisChris Whitfield
Sep 20, 2005·Molecular Plant-microbe Interactions : MPMI·Anke BeckerLarissa Sharypova
Jan 13, 2006·Molecular Plant-microbe Interactions : MPMI·Maribel ParadaJosé E Ruiz-Sainz
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May 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Olga G OvchinnikovaChris Whitfield
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Mar 2, 2021·Frontiers in Plant Science·Lucas G CastellaniGonzalo A Torres Tejerizo
Jul 3, 2021·International Journal of Molecular Sciences·Sebastián Acosta-JuradoJosé-María Vinardell
Dec 7, 2011·The Journal of Organic Chemistry·Yuxin QianChang-Chun Ling

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