Sinus histiocytosis with massive lymphadenopathy (SHML) prednisone resistant but dexamethasone sensitive

Pediatric Blood & Cancer
Kimo C Stine, Christopher Westfall

Abstract

Sinus histiocytosis with massive lymphadenopathy (SHML) is a histiocytic disorder affecting children and adults. It usually presents as markedly enlarged lymph nodes that require surgical biopsy for confirmation. This lesion is usually self-limited but can present in areas that can cause significant morbidity or disfigurement. We report a case that required therapy due to the severe disfigurement but was resistant till treated with dexamethasone. This case illustrates that SHML may be resistant to prednisone but still be sensitive to dexamethasone.

Citations

Apr 20, 2006·European Journal of Pediatrics·Mercedes Bernácer-BorjaCarmen Rivas-Manga
Jul 6, 2007·La Presse médicale·Lionel GalicierEric Oksenhendler
Sep 21, 2010·The British Journal of Dermatology·G Le GuennoE Oksenhendler
Mar 1, 2016·La Presse médicale·Lionel GalicierVéronique Meignin
Apr 19, 2013·American Journal of Clinical Pathology·Xuefeng ZhangJames Vardiman
Apr 20, 2005·Pediatric Blood & Cancer·Susumu Inoue, Nkechi Onwuzurike
Mar 21, 2013·European Journal of Gastroenterology & Hepatology·Bulent BaranSabahattin Kaymakoglu
May 24, 2017·British Journal of Neurosurgery·Shashank S JoshiKishor A Choudhari

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