Oct 1, 1989

Sinus node dysfunction and sudden cardiac death following treatment with encainide

Pacing and Clinical Electrophysiology : PACE
R LemeryD Roy

Abstract

Encainide, a class Ic drug, is generally thought of as having little effect on sinus node function. In this article, we present the clinical course and electrophysiological findings of a patient who had cardiac arrest after 1 week of encainide therapy for ventricular extrasystoles. No ventricular tachyarrhythmias were induced during programmed ventricular stimulation (baseline study and while receiving encainide therapy). Prior to encainide therapy, sinus node function was normal, but clinical observations after admission for cardiac arrest and subsequent electrophysiological study revealed that encainide had caused striking impairments in sinus node function. During a 6-month follow-up without antiarrhythmic drug treatment, this patient has had an uneventful course. We concluded that encainide can cause severe and life-threatening sinus node dysfunction.

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Mentioned in this Paper

Anilides
Cessation of Life
Anti-Arrhythmia Agents
Cardiac Depressants
Electrophysiology (Science)
Heart Ventricle
Sinus Node Dysfunction (Disorder)
Encainide, (-)-Isomer
Sinus Arrhythmia
Cardiac Pacing, Artificial

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