Sinus slowing produced by intracoronary arterial injections of hyperosmotic solutions in man

American Heart Journal
S AbeT Kobayashi


The effect of intracoronary arterial injections of normal saline, contrast agent, hyperosmotic glucose, and mannitol solutions on the sinus rate was studied in 18 patients. Sinus slowing was not produced by isosmotic saline (0.3 Osm. per kilogram of water) when injected into either coronary artery, whereas 76% Urografin (1.9 Osm. per kilogram of water), 20% glucose (1.3 Osm. per kilogram of water), and mannitol (1.2 Osm. per kilogram of water) decreased the sinus rate significantly (P less than 0.001). Among these solutions, Urografin with the highest osmolality produced the most marked sinus slowing, whereas no significant difference was detected between change in the sinus rate with hyperosmotic glucose and mannitol solutions (P greater than 0.5). Moreover, there was no significant difference between the degree of sinus slowing produced by intracoronary injections into the coronary artery of the side which the sinus node artery originated from and the slowing produced by contralateral injections with hyperosmotic solutions (P greater than 0.2). Therefore, it seems unlikely that this sinus slowing would be a result of a direct action on the sinus node including hypoxia and elevated perfusion pressure. Reflex-mediated parasympa...Continue Reading


May 1, 1970·British Heart Journal·D C BanksS Oram
Jun 2, 1966·The New England Journal of Medicine·A Benchimol, E M McNally
Oct 1, 1966·Circulation·R N MacAlpinW N Hanafee
Jul 1, 1967·British Heart Journal·R L Coskey, O Magidson
Sep 1, 1963·American Heart Journal·T N JAMES, R A NADEAU
Jan 1, 1964·Radiology·G G GENSINI, S DIGIORGI
Oct 1, 1961·The Anatomical Record·T N JAMES

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Mar 1, 1990·Catheterization and Cardiovascular Diagnosis·C J MurdockG D Cope

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