Sipuleucel-T for the treatment of metastatic prostate cancer: promise and challenges

Human Vaccines & Immunotherapeutics
Channing J Paller, Emmanuel S Antonarakis

Abstract

In the past 18 mo, three new life-prolonging therapies have been approved by the US. Food and Drug Administration for the treatment of men with metastatic castration-resistant prostate cancer (mCRPC), including sipuleucel-T, the first therapeutic vaccine approved for this disease. With very low toxicity and a demonstrable overall survival benefit, sipuleucel-T offers a promising new therapy and validates further investigation into other immunotherapy approaches for prostate cancer patients. However, questions about its mechanism of action, concerns about its cost, and its optimal sequencing in the prostate cancer treatment landscape may be limiting the adoption of sipuleucel-T. This review summarizes the state-of-the-science with respect to immunotherapy approaches for men with prostate cancer, provides information about the clinical development as well as the strengths and concerns associated with sipuleucel-T, and offers initial insights about where this promising treatment may best fit in the therapeutic landscape.

References

Jul 1, 1995·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·E M JaffeeD M Pardoll
Jan 1, 1997·Annual Review of Immunology·J J DonnellyM A Liu
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·E D KwonM B Burg
Dec 1, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E J SmallF H Valone
Nov 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony V D'AmicoDelray Schultz
Mar 29, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan HalabiNicholas J Vogelzang
Oct 8, 2004·The New England Journal of Medicine·Ian F TannockUNKNOWN TAX 327 Investigators
Sep 24, 2005·The New England Journal of Medicine·Xiaoju WangArul M Chinnaiyan
May 30, 2006·Advances in Immunology·Charles G DrakeDrew M Pardoll
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jonathan W SimonsWilliam G Nelson
Jul 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric J SmallRobert M Hershberg
Aug 2, 2006·British Journal of Cancer·B S TaylorA M Chinnaiyan
Oct 6, 2006·Expert Review of Anticancer Therapy·Rosendo So-Rosillo, Eric J Small
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eric J SmallJonathan W Simons
Jan 10, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dominik R BertholdIan F Tannock
Jul 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ravi A MadanPhilip M Arlen
Sep 5, 2008·Expert Review of Vaccines·Bruce Acres, Jean-Yves Bonnefoy
Mar 17, 2009·Future Oncology·Philip M ArlenJames L Gulley
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas G McNeelGeorge Wilding
Jan 27, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip W KantoffWayne R Godfrey
Jun 3, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Julie R BrahmerSuzanne L Topalian
Jun 8, 2010·The New England Journal of Medicine·F Stephen HodiWalter J Urba
Jul 9, 2010·CA: a Cancer Journal for Clinicians·Ahmedin JemalElizabeth Ward
Aug 11, 2010·Archives of Internal Medicine·Edward M UchioJohn Concato
Sep 8, 2010·The New England Journal of Medicine·Philip W KantoffUNKNOWN IMPACT Study Investigators
Sep 10, 2010·Journal of the National Cancer Institute·Axel HoosJedd Wolchok
Jan 29, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A M HorganN B Leighl
May 12, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tomasz M BeerMark W Frohlich
May 27, 2011·The New England Journal of Medicine·Johann S de BonoUNKNOWN COU-AA-301 Investigators
May 27, 2011·The New England Journal of Medicine·Emmanuel S Antonarakis, Mario A Eisenberger
Aug 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edward Cha, Lawrence Fong

❮ Previous
Next ❯

Citations

Jan 19, 2013·Chinese Journal of Cancer·Kenneth C ValkenburgZhendong Zhong
Oct 3, 2014·BioMed Research International·Brian Wan-Chi TsePamela Joan Russell
Sep 26, 2015·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Szymon Jarosławski, Mondher Toumi
Jul 15, 2015·BioMed Research International·Ida SilvestriAlessandro Sciarra
May 29, 2014·Clinical Journal of Oncology Nursing·Rajni KannanStephanie Andrews
May 24, 2013·International Journal of Molecular Sciences·Sakthivel MuniyanMing-Fong Lin
Jul 31, 2012·Clinical Medicine Insights. Oncology·Sosipatros A Boikos, Emmanuel S Antonarakis
Aug 9, 2017·The Prostate·Channing J PallerNorma F Kanarek
Jan 18, 2017·Mathematical Biosciences and Engineering : MBE·Alacia M VothEdward W Swim
Jun 13, 2020·International Reviews of Immunology·Sidhant Jain, Sahil Kumar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.