siRNA in ovarian cancer - Delivery strategies and targets for therapy

Journal of Controlled Release : Official Journal of the Controlled Release Society
Dirk van den BrandRoland Brock

Abstract

Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, and the sixth leading cause of cancer related death in women overall. Despite improved surgical techniques and advances in chemotherapy, mortality hardly decreased over the last twenty years. The major problem is that (micro)metastases persevere in the abdominal cavity, causing incurable tumor recurrence. Therefore, there is an imminent need for new therapeutic strategies. Oligonucleotide (ON) based therapies such as RNA interference (RNAi) provide the possibility to specifically address disease-related pathways. However, small interfering RNA (siRNA) molecules are unable to enter cells without a drug delivery system. Therefore, nanocarriers have been developed to aid intracellular delivery of siRNA. EOC is, in most cases, confined to the abdominal cavity, providing the possibility for peritoneal drug delivery. As a consequence, EOC should be an ideal candidate for ON therapies as intraperitoneal delivery reduces sequestration of drug formulations in other organs. In this review, we will discuss delivery strategies and siRNA targets that have been tested in EOC. Delivery strategies cover the full range of delivery approaches from polymers to exotic del...Continue Reading

Citations

Oct 3, 2018·International Journal of Molecular Sciences·Guang-Jer Wu
Apr 2, 2019·Expert Opinion on Biological Therapy·Youngwoo ChoMansoor M Amiji
Dec 25, 2019·IUBMB Life·Maryam ChamaniZatollah Asemi
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