Abstract
Epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy, and the sixth leading cause of cancer related death in women overall. Despite improved surgical techniques and advances in chemotherapy, mortality hardly decreased over the last twenty years. The major problem is that (micro)metastases persevere in the abdominal cavity, causing incurable tumor recurrence. Therefore, there is an imminent need for new therapeutic strategies. Oligonucleotide (ON) based therapies such as RNA interference (RNAi) provide the possibility to specifically address disease-related pathways. However, small interfering RNA (siRNA) molecules are unable to enter cells without a drug delivery system. Therefore, nanocarriers have been developed to aid intracellular delivery of siRNA. EOC is, in most cases, confined to the abdominal cavity, providing the possibility for peritoneal drug delivery. As a consequence, EOC should be an ideal candidate for ON therapies as intraperitoneal delivery reduces sequestration of drug formulations in other organs. In this review, we will discuss delivery strategies and siRNA targets that have been tested in EOC. Delivery strategies cover the full range of delivery approaches from polymers to exotic del...Continue Reading
Citations
Oct 3, 2018·International Journal of Molecular Sciences·Guang-Jer Wu
Apr 2, 2019·Expert Opinion on Biological Therapy·Youngwoo ChoMansoor M Amiji
Dec 25, 2019·IUBMB Life·Maryam ChamaniZatollah Asemi
Mar 3, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jing ZhaoYakai Feng
Sep 15, 2018·Mass Spectrometry·Yuko Nakashima, Mitsutoshi Setou
Jun 27, 2019·Pharmaceutical Research·Molood ShariatiKatrien Remaut
Oct 28, 2019·Pharmaceutics·Rossella FarraGabriele Grassi
Feb 18, 2021·Nucleic Acid Therapeutics·Sumit GangopadhyayKiran R Gore
Mar 14, 2021·Carbohydrate Polymers·Milad AshrafizadehRajender S Varma
Apr 3, 2021·Frontiers in Pharmacology·Zhili TianLei Zhang
May 18, 2021·Frontiers in Cell and Developmental Biology·Toshihiko TakeiwaSatoshi Inoue
Jun 19, 2021·Drug Delivery·Aixue LiJiyong Liu
Jul 3, 2021·Cancers·Cassie LiuAdam R Karpf
Jul 3, 2021·Cancers·Amal A Al-DossaryAbdulaziz M Almalik
Jul 27, 2021·Frontiers in Cell and Developmental Biology·Wen Yin, Su-Min Qian
Feb 20, 2019·ACS Applied Materials & Interfaces·Yue CaoQing-Ri Cao
Dec 6, 2018·Nano Letters·Zhelong LiLijun Yuan
Dec 22, 2021·Nanomedicine·Abdus SubhanVladimir P Torchilin