Sirolimus-eluting coronary stents in small vessels

American Heart Journal
Bernhard MeierSVELTE Study Group

Abstract

This prospective multicenter study compared angiographic in-lesion late lumen loss in de novo native coronary artery lesions (vessel diameter range 2.25-2.75 mm, length range > or = 15 to < or = 30 mm) 8 months after the implantation of a sirolimus-eluting stent with that of similar vessels with the same drug-eluting stent or a bare stent of the SIRIUS study (historical controls). One hundred one patients (study group) were matched and compared with 323 patients receiving the bare stent (bare control group) and with 350 receiving the Cypher stent (Cypher control group) in the SIRIUS trial. Mean in-lesion late loss in the study group was lower than that in the bare control group (0.20 versus 0.76 mm, P < .0001) and not inferior to that in the Cypher control group (0.27 mm, P = .3). Adverse event rates (death and myocardial infarction) were similar between groups. At 8 months, target lesion revascularization rates were 0% in the study group, 13.2% in the bare control group (P < .001), and 4.6% in the Cypher control group (P = .03). The Cypher Bx Velocity stent was confirmed to be superior to the bare Bx Velocity stent in small coronary vessels in terms of in-lesion late loss 8 months after implantation.

References

Sep 1, 1995·Journal of the American College of Cardiology·G R DussaillantM B Leon
Jul 18, 2001·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·I C HsiehD Wu
Oct 3, 2001·Circulation·R KoningUNKNOWN BESMART (BeStent in Small Arteries) Trial Investigators
Jun 7, 2002·The New England Journal of Medicine·Marie-Claude MoriceUNKNOWN RAVEL Study Group. Randomized Study with the Sirolimus-Coated Bx Velocity Balloon-Expandable Stent in the Treatment of Patie
Mar 12, 2003·Circulation·Michael HaudeUNKNOWN Heparin-COAted STents in small coronary arteries Trial Investigators
Aug 2, 2003·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Ronald P CaputoDonald S Baim
Dec 12, 2003·Cardiology in Review·Sandeep T Laroia, Archana T Laroia
Jan 30, 2004·Annual Review of Medicine·T Cooper Woods, Andrew R Marks
Feb 21, 2004·Journal of the American College of Cardiology·Dan GreenbergDavid J Cohen
Mar 5, 2004·The American Journal of Cardiology·Pedro A LemosPatrick W Serruys
Mar 19, 2004·Journal of the American College of Cardiology·Erick SchampaertUNKNOWN C-SIRIUS Investigators
Mar 23, 2004·Current Drug Targets. Cardiovascular & Haematological Disorders·M FroeschlE R O'Brien
Jun 3, 2004·Journal of the American College of Cardiology·Raúl MorenoCarlos Macaya
Dec 9, 2004·JAMA : the Journal of the American Medical Association·Diego ArdissinoUNKNOWN SES-SMART Investigators

❮ Previous
Next ❯

Citations

Feb 23, 2010·JACC. Cardiovascular Interventions·Daniel ChamiéJ Eduardo Sousa
Jun 22, 2007·Vascular Health and Risk Management·Alexandre Abizaid
Nov 9, 2010·Vascular Health and Risk Management·Sudhir Rathore
Aug 1, 2007·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Ricardo Seabra-GomesHenrique Cyrne Carvalho
Nov 16, 2010·Medical Engineering & Physics·David M Martin, Fergal J Boyle
Dec 29, 2015·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Hiroyuki JinnouchiKenji Ando
Jul 6, 2010·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Giuseppe Biondi-ZoccaiImad Sheiban
May 24, 2008·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Eugenia NikolskyMartin B Leon
Dec 15, 2007·Cardiovascular Drug Reviews·Ajay J Kirtane, Martin B Leon
Aug 26, 2010·Journal of Interventional Cardiology·Nirat BeoharCharles J Davidson
Nov 29, 2011·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Louis A CannonMarco A Costa
May 16, 2015·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Justin Z LeeKwan S Lee
Jul 4, 2006·Journal of the American College of Cardiology·Dean J KereiakesJeffrey W Moses
Feb 20, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·W J M DerksenG Pasterkamp
Mar 22, 2014·Journal of cardiology·Tatsuya SugaShunichi Miyazaki
Nov 21, 2016·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Manish A ParikhAjay Kirtane
May 11, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sebastian VölzElmir Omerovic

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.