Sirolimus-induced inflammatory papules with acquired reactive perforating collagenosis

Dermatology : International Journal for Clinical and Investigative Dermatology
J LübbeI Masouyé

Abstract

Sirolimus is an immunosuppressive macrolide with antineoplasic properties that is increasingly used in posttransplantation immunosuppression. The treatment is frequently associated with cutaneous side effects such as sirolimus-associated acneiform facial dermatitis, which has been observed in up to 50% of treated patients. We report a 51-year-old female with liver transplantation who developed inflammatory papules and nodules on the face and the upper chest 3 weeks after the initiation of sirolimus therapy. Sequential biopsies revealed lymphocytic infiltration of the dermis with a peculiar pattern of sebotropism, while older lesions showed acquired reactive perforating collagenosis. The lesions were responsive to hydroxychloroquine treatment despite continued sirolimus treatment.

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Citations

Jun 15, 2011·American Journal of Clinical Dermatology·Aurélie Du-ThanhBernard Guillot
May 30, 2013·Indian Journal of Dermatology·Emiliano GrilloPedro Jaén
Jul 21, 2010·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Maria Rosa CostanzoUNKNOWN International Society of Heart and Lung Transplantation Guidelines
May 31, 2013·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Gunnar Wagner, Michael Max Sachse
Jun 22, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Judit LukácsPeter Elsner
Jul 11, 2018·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Judit LukácsPeter Elsner
Dec 27, 2019·International Journal of Dermatology·Pedro Miguel GarridoPaulo Filipe
Jul 6, 2021·Indian Journal of Dermatology, Venereology and Leprology·Xia JiangFei Hao

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