Sirolimus therapy for fibromatosis and multifocal renal cell carcinoma in a child with tuberous sclerosis complex

Pediatric Blood & Cancer
Joseph G PresseyDavid R Kelly

Abstract

A male with tuberous sclerosis complex (TSC) developed a chest wall fibromatosis and bilateral multifocal renal cell carcinoma (RCC). The fibromatosis tumor was initially resected during infancy but recurred 5 years later. At that time, bilateral RCC was also detected, leading to the resection of the more extensively affected right kidney. In an attempt to avoid bilateral nephrectomies, the patient was treated with the mTOR inhibitor sirolimus. Within 6 months of therapy, the fibromatosis and remaining RCC tumors responded substantially with minimal adverse effects.

References

Apr 1, 1991·Urology·R Washecka, M Hanna
Feb 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Y MiyamotoY Hayashi
Mar 29, 2002·Medical and Pediatric Oncology·Ricardo Cabanas ArmadaJoaquín Pascual
Dec 28, 2004·Pathology Oncology Research : POR·Roberto Vargas-GonzalezFabiola Lara-Hernandez
Dec 30, 2004·Nature Genetics·Ken InokiKun-Liang Guan
Feb 3, 2006·Annals of Neurology·David Neal FranzKerry R Crone
Mar 24, 2006·Brain & Development·Ji-Eun ChoiKi-Joong Kim
Sep 29, 2006·The New England Journal of Medicine·Peter B CrinoElizabeth Petri Henske
Mar 31, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Raul Negrão FleuryCarla Ruffeil Moreira
Jul 20, 2007·Pediatric Blood & Cancer·Peter J HoughtonMalcolm A Smith
Oct 20, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Maryam FouladiWayne L Furman
Jan 11, 2008·The New England Journal of Medicine·John J BisslerDavid N Franz
Oct 23, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Khin ThwayNeil J Sebire
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij

❮ Previous
Next ❯

Citations

Jun 5, 2014·Current Oncology Reports·Aaron WeissDamon Reed
Dec 27, 2015·Seminars in Pediatric Neurology·Romina MoaveroPaolo Curatolo
Oct 20, 2011·Journal of Pediatric Surgery·Masako KuboToshiyuki Yamamoto
Jul 14, 2016·The Cochrane Database of Systematic Reviews·Teguh H SasongkoZamh Zabidi-Hussin
Mar 12, 2019·The Cochrane Database of Systematic Reviews·Esmee Cm KooijmansMargreet A Veening
Sep 2, 2020·Pediatric Blood & Cancer·Satyajit RayDermot Murphy
Apr 8, 2017·Oxidative Medicine and Cellular Longevity·Filipe PalavraFlávio Reis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.