Sirolimus therapy for patients with adult polycystic kidney disease: a pilot study

Transplantation Proceedings
A SolimanA Lotfy

Abstract

A pilot study was performed on adult polycystic kidney disease (PCKD) patients to examine the effects of the anti-proliferative mammalian target of rapamycin inhibitor sirolimus on the growth of renal cysts. Eight consecutive PCKD patients were given sirolimus (1 mg/d PO) for 6 consecutive months, in addition to an angiotensin receptor blocker (ARB), namely telmisartan. Another 8 PCKD patients served as a control group given only telmisartan. All PCKD patients had a serum creatinine value <2 mg/dL with a negative urine culture before enrollment. All patients were diagnosed by renal magnetic resonance imaging (MRI) to measure renal volumes. After a 6-month follow-up, patients were rescanned to remeasure the MRI volumes. Renal function was stable in 5/8 subjects in the sirolimus group, improved in 2 cases, and worsened in 1 with an increase of serum creatinine to >2 mg/dL resulting in his withdrawal after 5 months of follow-up. In contrast, the serum creatinine value was stable in 3 control group subjects, worsen in 3, and improved in 2. Four patients in the sirolimus group experienced infectious complications, namely, urinary tract infections (UTI) in 2 which were treated with antibiotics, and monilial pharyngitis in 2, who were...Continue Reading

References

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Citations

Dec 1, 2012·Transplantation Proceedings·A SolimanE Ismail
May 12, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ahsan AlamDaniel G Bichet
Jul 15, 2015·The Cochrane Database of Systematic Reviews·Davide BolignanoGiovanni F M Strippoli
Apr 12, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Rex L Mahnensmith
May 26, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Vicente E TorresRudolf P Wüthrich

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