SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma

The American Journal of Surgical Pathology
Kyu Yun JangWoo Sung Moon

Abstract

Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase. Recently, it is suggested that SIRT1 may be involved in the development of malignant tumors including mouse lymphoma. Therefore, we investigated the prevalence and the prognostic impact of SIRT1 expression in diffuse large B-cell lymphoma (DLBCL). Immunohistochemical expression of SIRT1, p53, bcl2, CD10, bcl6, and multiple myeloma-1 (MUM1) were evaluated by using a 2 mm core from 104 DLBCL patients for tissue microarray. Positive expression of SIRT1 was seen in 74% (77/104) of patients. In total DLBCL patients, SIRT1 and p53 expression were significantly associated with shorter overall survival (OS) by univariate analysis (P=0.001 and P=0.011, respectively). SIRT1 was also an independent prognostic factor by multivariate analysis (P=0.01). According to the expression patterns of CD10, bcl6, and MUM1, germinal center B cell (GCB) types were represented in 38 cases (37%) and non-GCB types were represented in 66 cases (63%). In the GCB type, only p53 expression was associated with a significantly shorter OS (P=0.032). In the non-GCB type, expression of SIRT1 correlated with shorter OS by univariate analyses (P=0.005) and multivariate analyses (P=0.049)....Continue Reading

References

Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B D ChesonG P Canellos
Oct 24, 2001·Cell·H VaziriR A Weinberg
Jan 25, 2002·The New England Journal of Medicine·Bertrand CoiffierChristian Gisselbrecht
Jun 21, 2002·The New England Journal of Medicine·Andreas RosenwaldUNKNOWN Lymphoma/Leukemia Molecular Profiling Project
Aug 15, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K LeroyUNKNOWN Groupe d'Etude des Lymphomes de l'Adulte
Mar 17, 2004·Molecular Cell·Haim Y CohenDavid A Sinclair
Jun 11, 2004·Annual Review of Biochemistry·Gil Blander, Leonard Guarente
Feb 3, 2005·Proceedings of the National Academy of Sciences of the United States of America·Andrei KuzmichevDanny Reinberg
Mar 19, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Nobuko MatsushitaMinoru Takata
Jan 18, 2006·Annals of Hematology·Y H ParkUNKNOWN Lymphoma Study Division of the Korean Cancer Study Group
Feb 24, 2006·Nature Reviews. Cancer·Stephen B Baylin, Joyce E Ohm
May 3, 2006·Oncogene·L BelloniM Levrero
Jun 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas M HabermannSandra J Horning
Sep 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gustaaf W van ImhoffPhilip M Kluin
Dec 21, 2006·Archives of Dermatological Research·Yasutoshi HidaSeiji Arase
Apr 17, 2007·Cell Biology International·Chang-Su Lim
Jul 13, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Yuning SunShengqi Wang
Jul 20, 2007·Cancer Research·Derek M HuffmanTim R Nagy

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Citations

Apr 26, 2011·Oncogene·J FüllgrabeB Joseph
Jan 24, 2013·Molecular Endocrinology·Kimberly R HollowayKevin Pruitt
Jan 18, 2013·World Journal of Gastroenterology : WJG·Qin Huang
Apr 23, 2013·Oncogene·M Roth, W Y Chen
Oct 24, 2014·Cell Death & Disease·L MaB Brodin
May 25, 2013·Pathology, Research and Practice·Sang Jae NohMyoung Ja Chung
May 11, 2011·Biochimica Et Biophysica Acta·Anjan Kumar PradhanSoumen Chakraborty
Nov 26, 2014·Journal of Experimental & Clinical Cancer Research : CR·Yu-Wen CaoFeng Li
Jul 27, 2012·International Journal of Cancer. Journal International Du Cancer·Raffaele FrazziFrancesco Merli
Oct 12, 2012·Annals of the New York Academy of Sciences·Na-Young Song, Young-Joon Surh
Nov 17, 2009·British Journal of Haematology·Emma M SmithFaith E Davies
Apr 24, 2010·Cancer Science·Ji-Youn SungJuhie Lee
Apr 1, 2015·Journal of Ovarian Research·Dong ChoKyu Jang
Jun 15, 2011·Hematology·Marco Wiltgen, Gernot P Tilz
Aug 19, 2014·Journal of Hepatology·Zheng Yun ZhangSung Joo Kim
Aug 16, 2016·Biochemical and Biophysical Research Communications·Elizabeth H Cho, Yan Dai
Aug 26, 2011·International Journal of Surgical Pathology·An Ning FengJun Yang
Feb 11, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·David H MvuntaTanri Shiozawa

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