SIRT1 gene polymorphisms are associated with growth traits in Nanyang cattle

Molecular and Cellular Probes
Ming-xun LiHong Chen

Abstract

Growth is under complex genetic control and uncovering the molecular mechanisms how the genes and polymorphisms affect economic growth traits, are important for successful marker-assisted selection and more efficient management strategies in commercial cattle populations. SIRT1 is a NAD(+)-dependent deacetylase that belongs to the class III histone deacetylases. It plays an important role in numerous fundamental cellular processes including gene silencing, DNA repair, and metabolic regulation. In addition, SIRT1 acts as an inhibitor of adipogenesis and has been associated with body weight regulation. The objective of the present study was to identify single nucleotide polymorphisms (SNPs) of bovine SIRT1 using 1255 animals representing the five main Chinese breeds and to determine if these SNPs are associated with economically important traits in Nanyang cattle. The approach consisted of resequencing SIRT1 using a panel of DNA from unrelated animals of five different breeds and the process revealed five novel SNPs. SNPs g.17324T>C and g.17491G>A exhibited a high degree of linkage disequilibrium in all tested breeds. Seven major haplotypes accounting for 91.2% of the alleles were observed and the haplotype 'GCCGA' was the most c...Continue Reading

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Citations

Jul 28, 2016·Molecular and Cellular Probes·Mei LiuHong Chen
Aug 16, 2016·Genetics, Selection, Evolution : GSE·Silvia SorboliniNicolò Pietro Paolo Macciotta
Apr 16, 2020·Animals : an Open Access Journal From MDPI·Mingxun LiYongjiang Mao
Nov 2, 2018·Archives Animal Breeding·Xiaomei SunZhangping Yang
Jul 7, 2018·Science·Kevin G DalyDaniel G Bradley
Nov 16, 2021·Animal Biotechnology·Sayed Haidar Abbas RazaLinsen Zan

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