SIRT1 in B[a]P-induced lung tumorigenesis

Oncotarget
Jianyi LuJimin Gao

Abstract

Benzo[a]pyrene (B[a]P) is a carcinogen in cigarette smoke. We found that B[a]P induced SIRT1 in human bronchial epithelial BEAS-2B cell. SIRT1 was overexpressed in the lung of B[a]P-exposed mice and in human lung cancer biopsies. SIRT1 up-regulated TNF-α and β-catenin and down-regulated the membrane fraction of E-cadherin. In addition, SIRT1 promoted invasion, migration and tumorigenesis of BEAS-2B cells in nude mice upon B[a]P exposure. Thus, SIRT1 is involved in B[a]P-induced transformation associated with activation of the TNF-α/β-catenin axis and is as a potential therapeutic target for lung cancer.

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Citations

Feb 1, 2018·Oncotarget·Fabiana M MelisoMiriam G Jasiulionis
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Methods Mentioned

BETA
acetylation
biopsies
PCR
biospies
transfection
FACS
nuclear translocation
transfections
electrophoresis

Software Mentioned

Image
Image Pro Plus
Pro Plus

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