Sirt1 in cerebral ischemia

Brain Circulation
Kevin B Koronowski, Miguel A Perez-Pinzon

Abstract

Cerebral ischemia is among the leading causes of death worldwide. It is characterized by a lack of blood flow to the brain that results in cell death and damage, ultimately causing motor, sensory, and cognitive impairments. Today, clinical treatment of cerebral ischemia, mostly stroke and cardiac arrest, is limited and new neuroprotective therapies are desperately needed. The Sirtuin family of oxidized nicotinamide adenine dinucleotide (NAD(+))-dependent deacylases has been shown to govern several processes within the central nervous system as well as to possess neuroprotective properties in a variety of pathological conditions such as Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease, among others. Recently, Sirt1 in particular has been identified as a mediator of cerebral ischemia, with potential as a possible therapeutic target. To gather studies relevant to this topic, we used PubMed and previous reviews to locate, select, and resynthesize the lines of evidence presented here. In this review, we will first describe some functions of Sirt1 in the brain, mainly neurodevelopment, learning and memory, and metabolic regulation. Second, we will discuss the experimental evidence that has implicated Sirt1 as a key ...Continue Reading

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Citations

Jun 21, 2016·Neurological Research·Kaiyin LiuYuchuan Ding
Aug 9, 2016·Reviews in the Neurosciences·Siew Ying Wong, Bor Luen Tang
Jul 8, 2017·Antioxidants & Redox Signaling·Nathalie KhouryMiguel A Perez-Pinzon
Jul 13, 2016·Journal of Neuroscience Research·Bor Luen Tang
Oct 21, 2017·Frontiers in Cellular Neuroscience·Fengwu LiYuchuan Ding
Jan 24, 2019·Frontiers in Cell and Developmental Biology·Charles K DavisG K Rajanikant
Dec 12, 2018·Frontiers in Endocrinology·Jing XuMiguel A Perez-Pinzon
Dec 13, 2016·Cellular and Molecular Neurobiology·Bor Luen Tang
Oct 9, 2020·Immunological Investigations·Fatemeh Sabet Sarvestani, Negar Azarpira
Feb 13, 2021·International Journal of Environmental Research and Public Health·Stefania D'AngeloRosaria Meccariello
May 1, 2021·International Journal of Molecular Sciences·Liangyu HuDeli Zhang
Jun 29, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Zirong PanGuanhua Du
Jan 14, 2021·Journal of the American Chemical Society·Qingxia HuangDaqing Zhao

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