SIRT1 variants are associated with aging in a healthy Han Chinese population

Clinica Chimica Acta; International Journal of Clinical Chemistry
Wei-Guang ZhangXiang-Mei Chen

Abstract

Aging is influenced by diverse environmental and genetic risk factors. The SIRT1 (silent information regulator 1) gene has been shown to regulate lifespan and aging in previous studies. We determined whether variation in the SIRT1 gene is associated with aging in healthy Chinese population. The study population comprised 482 healthy, unrelated Chinese subjects, of which 246 were aging individuals from 60 to 91years old, and 236 younger individuals from 35 and 59years old. All subjects were from Shenyang, China. Two single-nucleotide polymorphisms (SNP) were analyzed: rs3758391 near the 5' end of the SIRT1 gene; and rs4746720, in the 3' untranslated region. Differences in allele and genotype frequency were seen between the groups, with rs3758391/C more common than rs3758391/T in the aging subjects (odds ratio=1.453, p=0.026), and with rs3758391/CC more common than rs3758391/CT and rs3758391/TT in the aging subjects (odds ratio=3.042, p=0.027). For the 3' SNP, rs4746720/C was more common than rs4746720/T in the aging subjects (odds ratio=1.347, p=0.022), and rs4746720/CC was more common than rs4746720/CT and rs4746720/CT in the aging subjects (odds ratio=1.461, p=0.049). The haplotype frequency distribution was also different, wi...Continue Reading

References

Mar 20, 2001·American Journal of Human Genetics·M StephensP Donnelly
Aug 15, 2001·American Journal of Medical Genetics·B D MitchellA R Shuldiner
Jun 4, 2004·Nature·Frédéric PicardLeonard Guarente
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Feb 9, 2005·American Journal of Human Genetics·Matthew Stephens, Paul Scheet
Aug 2, 2005·Cell Metabolism·Katrin F ChuaFrederick W Alt
Aug 23, 2005·Lancet·A M ValdesT D Spector
Nov 1, 2005·Experimental Gerontology·Friederike FlachsbartAlmut Nebel
Dec 13, 2005·Science·Danica ChenLeonard Guarente
Feb 9, 2006·Neurobiology of Aging·Bor Luen Tang
Jun 8, 2006·Annual Review of Biochemistry·Anthony A SauveJef D Boeke
Jul 29, 2006·Cell·Valter D Longo, Brian K Kennedy
Dec 19, 2006·Cell·Seung-Hoi Koo, Marc Montminy
Apr 21, 2007·Circulation Research·Ralph R AlcendorJunichi Sadoshima
Sep 27, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maris KuningasDiana van Heemst
Oct 26, 2007·Cell Biology International·Hai-Yan ShanXiang-Mei Chen
Sep 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Antero SalminenKai Kaarniranta
Jan 20, 2009·Current Pharmaceutical Design·Nica M Borradaile, J Geoffrey Pickering
Jan 27, 2009·Free Radical Biology & Medicine·M Carola ZillikensHuibert A P Pols
Feb 18, 2009·Cell Cycle·Munekazu Yamakuchi, Charles J Lowenstein
Feb 21, 2009·Science·Sandy D WesterheideRichard I Morimoto
Mar 3, 2009·Cellular Signalling·Antero Salminen, Kai Kaarniranta
May 16, 2009·Expert Opinion on Therapeutic Patents·Francisco J Alcaín, José M Villalba

❮ Previous
Next ❯

Citations

Jun 2, 2014·Heart, Lung & Circulation·Wei-Guang ZhangXiang-Mei Chen
Apr 17, 2013·Joint, Bone, Spine : Revue Du Rhumatisme·Odile GabayMichael W McBurney
Nov 6, 2012·Arthritis and Rheumatism·Odile GabayMichael W McBurney
Aug 28, 2014·Ageing Research Reviews·Dolores Corella, José M Ordovás
Dec 4, 2014·The Journal of Nutrition, Health & Aging·W-G ZhangX-M Chen
Mar 23, 2017·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Shajjia RaziDavid G Le Couteur
Jun 27, 2019·The Proceedings of the Nutrition Society·Janice E Drew
Feb 27, 2014·Molecular Biology Reports·Camila Rosat ConsiglioJosé Artur Bogo Chies
Sep 6, 2020·Talanta·M D Luque de Castro, R Quiles-Zafra

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis