Sirtinol attenuates hepatic injury and pro-inflammatory cytokine production following trauma-hemorrhage in male Sprague-Dawley rats

Acta Anaesthesiologica Scandinavica
F-C LiuH-P Yu

Abstract

Although studies have demonstrated that sirtinol administration following adverse circulatory conditions is known to be protective, the mechanism by which sirtinol produces the salutary effects remains unknown. We hypothesized that sirtinol administration in male rats following trauma-hemorrhage decreases cytokine production and protects against hepatic injury. Male Sprague-Dawley rats underwent trauma-hemorrhage (mean blood pressure 40 mmHg for 90 min, then resuscitation). A single dose of sirtinol (1 mg/kg of body weight) or vehicle was administered intravenously during resuscitation. Twenty-four hours thereafter, tissue myeloperoxidase (MPO) activity (a marker of neutrophil sequestration), cytokine-induced neutrophil chemoattractant (CINC)-1, CINC-3, intercellular adhesion molecule (ICAM)-1, and interleukin (IL)-6 levels in the liver and plasma alanine aminotransferase (ALT) concentrations were measured (n=6 Sprague-Dawley rats/group). Trauma-hemorrhage increased hepatic MPO activity, CINC-1, CINC-3, ICAM-1, and IL-6 levels and plasma ALT concentrations. These parameters were significantly improved in the sirtinol-treated rats subjected to trauma-hemorrhage. The salutary effects of sirtinol administration on attenuation of h...Continue Reading

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Citations

Jan 1, 2013·Journal of Anesthesia·Iosifina I KarmaniolouNikolaos F Arkadopoulos
Jun 12, 2013·PloS One·Huang-Ping YuTsong-Long Hwang
Aug 15, 2015·Mediators of Inflammation·Fu-Chao LiuHuang-Ping Yu
Jul 19, 2011·The Journal of Surgical Research·Yung-Fong TsaiHuang-Ping Yu
Jan 30, 2014·Transplant International : Official Journal of the European Society for Organ Transplantation·Eirini PantaziJoan Roselló-Catafau
Oct 15, 2014·International Endodontic Journal·M R ShinE-C Kim
Nov 2, 2017·Cell & Bioscience·Qing YeQuanxing Wang
May 16, 2009·Expert Opinion on Therapeutic Patents·Francisco J Alcaín, José M Villalba
Mar 21, 2013·The Journal of Trauma and Acute Care Surgery·Fu-Chao LiuHuang-Ping Yu
Apr 30, 2021·Heliyon·Kássya Mycaela Paulino SilvaAna Janaina Jeanine M de Lemos Jordão

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