Sirtuin 1 attenuates nasal polypogenesis by suppressing epithelial-to-mesenchymal transition

The Journal of Allergy and Clinical Immunology
Mingyu LeeHyun-Woo Shin

Abstract

Nasal polyps (NPs) imply a refractory clinical course in patients with chronic rhinosinusitis (CRS). Previously, we showed that hypoxia-inducible factor (HIF) 1 could mediate nasal polypogenesis through epithelial-to-mesenchymal transition (EMT). Sirtuin 1 (SIRT1), a histone deacetylase, reportedly suppresses the transcriptional activity of HIF-1. Thus we hypothesized that SIRT1 attenuates nasal polyposis by inhibiting HIF-1-induced EMT. We sought to determine the role of SIRT1 in patients with nasal polyposis. The effects of SIRT1 on nasal polypogenesis were investigated in previously developed murine models. Immunohistochemistry, immunoblotting, and immunoprecipitation were done to evaluate SIRT1, EMT, and hypoxic markers in human nasal epithelial cells or sinonasal tissues from the mice and the patients with CRS with or without NPs. SIRT1 transgenic mice had significantly fewer mucosal lesions with epithelial disruption and fewer NPs than wild-type (WT) mice. In addition, resveratrol (a SIRT1 activator) treatment suppressed nasal polypogenesis in WT mice; however, sirtinol (a SIRT1 inhibitor) administration increased the polyp burden in SIRT1 transgenic mice. In sinonasal specimens from patients with CRS, SIRT1 was downregul...Continue Reading

References

Oct 4, 2003·Nature Reviews. Drug Discovery·Amato GiacciaRandall S Johnson
Dec 4, 2004·The Journal of Allergy and Clinical Immunology·Seung-Heon ShinHirohito Kita
Nov 3, 2006·Genes & Development·Marcia C Haigis, Leonard P Guarente
Jan 5, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Sook Young LeeYoung Kyoon Kim
Feb 8, 2007·American Journal of Rhinology·Aleena BanerjiDaniel L Hamilos
Aug 19, 2007·Annals of Medicine·Nassim Dali-YoucefJohan Auwerx
Nov 27, 2007·The Journal of Clinical Investigation·Debra F HigginsVolker H Haase
Jul 29, 2008·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Chen-Yu ChienLing-Feng Wang
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Munekazu YamakuchiCharles J Lowenstein
Oct 2, 2008·Nature Reviews. Drug Discovery·Siva LavuPhilip D Lambert
May 2, 2009·American Journal of Respiratory and Critical Care Medicine·Tillie-Louise HackettDarryl A Knight
Jun 23, 2009·The Journal of Allergy and Clinical Immunology·Ping-Ping CaoZheng Liu
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Apr 23, 2010·Aging Cell·Gizem Donmez, Leonard Guarente
Jul 6, 2010·Biochemical and Biophysical Research Communications·Hyun-Woo ShinJong-Wan Park
Mar 25, 2011·Inflammation & Allergy Drug Targets·Manuele CasaleFabrizio Salvinelli
Jan 6, 2012·Current Opinion in Allergy and Clinical Immunology·Tillie-Louise Hackett
Feb 11, 2012·American Journal of Respiratory and Critical Care Medicine·Hyun-Woo ShinJong-Wan Park
Mar 8, 2012·Nature Reviews. Molecular Cell Biology·Riekelt H HoutkooperJohan Auwerx
Oct 30, 2012·Free Radical Biology & Medicine·Brian J Morris
Jan 15, 2013·The European Respiratory Journal·Sang-Nam LeeJoo-Heon Yoon
Jul 24, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Sinyi KongDeyu Fang
Jan 16, 2014·Biochemical and Biophysical Research Communications·Haejin YoonJong-Wan Park
Sep 25, 2014·Science Signaling·David M Gonzalez, Damian Medici
Sep 8, 2015·The Journal of Allergy and Clinical Immunology·Mingyu LeeHyun-Woo Shin

❮ Previous
Next ❯

Citations

Jul 6, 2016·Oxidative Medicine and Cellular Longevity·Raffaele PalmirottaFranco Silvestris
Sep 8, 2015·The Journal of Allergy and Clinical Immunology·Mingyu LeeHyun-Woo Shin
Mar 7, 2017·Immune Network·Roza KhalmuratovaHyun-Woo Shin
Jan 5, 2018·Laryngoscope Investigative Otolaryngology·Ahmed A Al-SayedEmad Massoud
May 17, 2018·American Journal of Respiratory Cell and Molecular Biology·Masanobu SuzukiSarah Vreugde
Apr 27, 2019·Experimental & Molecular Medicine·Seung Jin LeeChi Dae Kim
Nov 21, 2019·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Sophie GohyCharles Pilette
May 10, 2019·Cancer Cell International·Shentong YuJing Zhang
Sep 5, 2020·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Huankang ZhangDehui Wang
Feb 15, 2019·Frontiers in Pharmacology·Vincenzo CarafaAngela Nebbioso
Nov 9, 2019·Journal of Clinical Medicine·Doyeon KimJi Heui Kim
Nov 21, 2018·Frontiers in Immunology·Yong Ju JangJi Heui Kim
Feb 6, 2020·Allergy, Asthma & Immunology Research·Roza KhalmuratovaHyun Woo Shin
Jul 25, 2019·Allergy, Asthma & Immunology Research·Yi Sook KimHyun Woo Shin
Jul 7, 2020·American Journal of Rhinology & Allergy·Ting ZhangJing Chen
Sep 13, 2017·Laryngoscope Investigative Otolaryngology·Hyun-Woo Shin
Dec 8, 2020·Current Opinion in Allergy and Clinical Immunology·Gwanghui RyuHyun-Woo Shin
Sep 3, 2020·Clinical and Experimental Otorhinolaryngology·Roza Khalmuratova, Hyun-Woo Shin
Mar 6, 2021·The Journal of Allergy and Clinical Immunology·Jin Youp KimDae Woo Kim
May 7, 2021·The Journal of Allergy and Clinical Immunology·Mingyu LeeHyun-Woo Shin
Jul 3, 2021·Allergy, Asthma & Immunology Research·Yi Sook Kim, Hyun Woo Shin
Jul 27, 2021·Frontiers in Allergy·Erik D AndersonIan A Myles

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Hyun-Woo ShinJong-Wan Park
The Annals of Otology, Rhinology, and Laryngology
Neil Bhattacharyya
Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale
Leonardo BalsalobreLuc L M Weckx
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery
Junhua WuYanping Yu
© 2021 Meta ULC. All rights reserved