Sirtuin 1 regulates lipid metabolism associated with optic nerve regeneration

Molecular Medicine Reports
Yan ZhangShihui Wei

Abstract

Injury to the optic nerve may lead to axonal degeneration, followed by the gradual death of retinal ganglion cells (RGCs), which results in irreversible vision loss. In the present study the mechanism of optic nerve injury, and the following regeneration and repair processes associated with sirtuin 1 (SIRT1)‑regulated lipid metabolism were analyzed. In addition, the treatment of optic nerve injury using resveratrol was investigated. A rat model of optic nerve damage was prepared, and rats were divided into control, model and resveratrol groups. The model rats (with optic nerve damage) were treated with phosphate‑buffered saline or resveratrol once a day for seven, 14 and 21 days. The rats were then sacrificed and the optic nerve was dissected. The expression levels of SIRT1, sterol regulatory element‑binding protein 2 (SREBP‑2) and 3‑hydroxy‑3‑methylglutaryl‑CoA reductase (HMGCR) mRNA in the optic nerve were measured by reverse transcription‑quantitative polymerase chain reaction, and the protein expression of SIRT1, SREBP2 and HMGCR was evaluated by western blotting. In addition, the cholesterol level of the optic nerve was assessed. The retina was excised and the surviving RGCs were observed and counted. The morphology of the...Continue Reading

References

Apr 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B L Scott, N G Bazan
Jul 22, 2006·Nature Reviews. Neuroscience·Glenn Yiu, Zhigang He
Oct 17, 2007·Genes & Development·Michael PotenteStefanie Dimmeler
Jun 10, 2009·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Dennis R HoffmanDeborah A Diersen-Schade
Oct 10, 2009·Science·Darcie L MooreJeffrey L Goldberg
Jul 28, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shaday MichánValter D Longo
Nov 4, 2010·Nature Reviews. Neuroscience·Martin E Schwab
Jun 10, 2011·The New England Journal of Medicine·Leonard Guarente
Jan 6, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gizem DonmezLeonard Guarente
May 31, 2014·Trends in Neurosciences·Vincent Pernet, Martin E Schwab

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Citations

Apr 26, 2018·International Journal of Molecular Medicine·Mengwen ZhouHuiming Zhang
Jun 12, 2021·Cutaneous and Ocular Toxicology·Sümeyye Burcu AgcayaziHalis Süleyman

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