Sirtuin 7: a new marker of aggressiveness in prostate cancer

Oncotarget
Romain HaiderDamien Ambrosetti

Abstract

Predictive biomarkers for advanced prostate cancer (PCa) are still missing. The sirtuin 7 (SIRT7) has been linked to tumorogenesis but its role in prostate cancer is poorly documented. To determine if SIRT7 can be a biomarker for aggressive prostate cancer and plays a role in PCa aggressiveness. We analyzed the expression of SIRT7 by immunohistochemistry in 57 patients comparing healthy with adjacent cancer tissue. SIRT7 levels were significantly elevated in tumors and its expression was positively associated with the grade. We also demonstrated that the knock down of SIRT7 decreased the migration of DU145 and PC3 cells (two androgen-independent prostate cancer cell lines) whereas the overexpression of the native protein but not the mutated form increased the cell migration and the invasion of the poorly aggressive prostate cancer cell line LNCaP. Finally, we also showed that SIRT7 overexpression induced the resistance to docetaxel. Our results demonstrate that SIRT7 promotes prostate cancer cell aggressiveness and chemoresistance and suggest that SIRT7 is a good predictive biomarker of PCa aggressiveness.

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Citations

Feb 15, 2019·Frontiers in Pharmacology·Vincenzo CarafaAngela Nebbioso
Feb 6, 2020·Journal of Experimental & Clinical Cancer Research : CR·Mao DingShu-Jie Xia
Dec 5, 2018·Frontiers in Endocrinology·Di WuWei-Guo Zhu
May 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ping FangXugeng Wang
Jun 10, 2021·Clinical Epigenetics·Catarina Macedo-SilvaLucia Altucci

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Methods Mentioned

BETA
acetylation
Flow cytometry
transfection

Software Mentioned

Image J

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