Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology

Pediatric Cardiology
Alessandro IanniThomas Braun

Abstract

Cardiovascular diseases represent a major cause of death and morbidity. Cardiac and vascular pathologies develop predominantly in the aged population in part due to lifelong exposure to numerous risk factors but are also found in children and during adolescence. In comparison to adults, much has to be learned about the molecular pathways driving cardiovascular diseases in the pediatric population. Sirtuins are highly conserved enzymes that play pivotal roles in ensuring cardiac homeostasis under physiological and stress conditions. In this review, we discuss novel findings about the biological functions of these molecules in the cardiovascular system and their possible involvement in pediatric cardiovascular diseases.

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Citations

Nov 6, 2018·Journal of Cellular Biochemistry·Sadiya Bi ShaikhYashodhar Prabhakar Bhandary
Jun 10, 2020·Cardiovascular Research·Giovanni Maroli, Thomas Braun
Jan 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Alessandro IanniThomas Braun
Jun 3, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Alberto ZulloWerner Klingler
May 25, 2021·Molecular & Cellular Oncology·Poonam KumariAlessandro Ianni

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Methods Mentioned

BETA
acetylation

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