Abstract
Thyroid hormones enhance the metabolic rate and the aerobic metabolism favoring oxidative stress, which is accompanied by induction of damage to cellular macromolecules including the DNA. The aim of the present study was to investigate the ability of thyroxine to induce sister chromatid exchange and micronuclei, and to modulate cell-cycle kinetics in cultured human lymphocytes. Eight experimental concentrations of thyroxine were used, ranging from 2 x 10(-9) to 0.5 x 10(-4)M. Treatment with thyroxine increased the frequency of SCE per cell at the higher concentrations (1.5 x 10(-6), 0.5 x 10(-5), 1.5 x 10(-5) and 0.5 x 10(-4)M). On the other hand, there were no significant aneugenic and/or clastogenic effects observed in the cytokinesis-block micronucleus assay. The results show that thyroxine acted as a relatively weak clastogen compared with the positive control N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). In addition to the genotoxic effects, two high concentrations of thyroxine decreased the mitotic index and caused cell-cycle delay. In conclusion, thyroxine exhibited weak clastogenic effects only at high concentrations. Therefore, effects in humans might appear in cases of acute thyroxine overdose.
References
Jun 1, 1975·Mutation Research·H J Evans, M L O'Riordan
Apr 1, 1992·International Journal of Cancer. Journal International Du Cancer·H IishiH Taniguchi
May 1, 1991·The Journal of Emergency Medicine·P D BerknerN Person
Apr 1, 1989·Clinical Endocrinology·R WilsonJ A Thomson
Apr 1, 1988·Mutation Research·P P van Buul, S C van Buul-Offers
Sep 13, 1974·Nature·P Perry, S Wolff
Dec 1, 1982·Mutation Research·P P van Buul, S van Buul-Offers
May 1, 1983·Mutation Research·L LambertiG Ardito
Feb 1, 1982·Scandinavian Journal of Immunology·T Paavonen
Jan 1, 1993·Mutation Research·M Fenech
Sep 1, 1993·Mutation Research·J D TuckerA V Carrano
Jul 1, 1994·Mutagenesis·J SurrallésR Marcos
Nov 1, 1993·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J M van ZylA Kriegler
Jan 1, 1993·Free Radical Research Communications·V Fernández, L A Videla
Sep 23, 1996·Mutation Research·N DjelićD Cvetković
Apr 29, 1999·Journal of Neuroscience Research·A H StokesK E Vrana
Dec 13, 2000·Mutation Research·M Fenech
Oct 20, 2001·Oncogene·S Lambert, B S Lopez
Dec 24, 2003·Teratogenesis, Carcinogenesis, and Mutagenesis·Ninoslav Djelic, Diana Anderson
Jun 25, 2004·Mutagenesis·Małgorzata M DobrzyńskaDiana Anderson
Jan 15, 2005·Annals of the New York Academy of Sciences·Ercole L Cavalieri, Eleanor G Rogan
Jan 18, 2005·Mutation Research·Günter Speit, Leigh Henderson
Citations
Feb 9, 2016·Indian Journal of Clinical Biochemistry : IJCB·Yogita S RautMgr Rajan
Mar 14, 2013·Critical Reviews in Toxicology·Larry D Kier, David J Kirkland
Feb 25, 2014·Acta Biologica Hungarica·Serap CeliklerM Ozel
Mar 6, 2012·Journal of Ethnopharmacology·Moustapha OuedraogoPierre Duez
Sep 15, 2009·Environmental Science & Technology·Davor ZeljezicBozica Radic