PMID: 489014Sep 1, 1979Paper

Sister chromatid exchange in peripheral lymphocytes of subjects vaccinated against measles

Human Genetics
B LambertB Werelius

Abstract

The SCE frequency was studied in cultures of peripheral lymphocytes from three subjects before and after vaccination against measles. The immunological vaccination reactions were monitored by antibody titration and by measurement of DNA synthesis in peripheral lymphocytes. In two of the subjects, on the 14th day after vaccination, there was a marked decrease of the SCE frequency coinciding with common clinical vaccination reactions and an increase of DNA synthesis in the peripheral lymphocytes. The increase of antibody titers started on the 17th day. One month later, when the immunological reactions had subsided, the SCE frequency was increased by 25% over the prevaccination level. Third subject displayed a delayed vaccination response due to a simultaneous influenza infection. This subject showed a 50% increase in the SCE frequency on the 14th day as well as 6 weeks after vaccination. These results suggest that significant changes in the SCE frequency may be related to immunological vaccination reactions.

References

Jan 1, 1977·Annual Review of Genetics·S Wolff

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Citations

Jan 1, 1991·American Journal of Industrial Medicine·S Milković-Kraus, D Horvat
Jan 1, 1986·International Archives of Occupational and Environmental Health·I StuckerD Hemon
Nov 16, 1992·Mutation Research·C SarriM Papamichail
Apr 1, 1994·Mutation Research·A TezelM Sakizli
Oct 1, 1983·Journal of Medical Genetics· VijayalaxmiB Pentland
Feb 1, 1984·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·T Sharma, B C Das

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