PMID: 7526171Nov 1, 1994Paper

Sister-chromatid exchanges, chromosomal aberrations and cytotoxicity produced by topoisomerase II-targeted drugs in sensitive (A2780) and resistant (A2780-DX3) human ovarian cancer cells: correlations with the formation of DNA double-strand breaks

Mutation Research
E NovielloP Russo

Abstract

Doxorubicin, ellipticine and etoposide are antineoplastic drugs with topoisomerase II inhibitory activity. The relationship between drug-induced sister-chromatid exchanges (SCEs) or chromosomal aberrations (CAs) and cytotoxicity, or drug-induced DNA double-strand breaks (DSBs) and cytotoxicity, or drug-induced SCEs and DSBs was investigated in human ovarian cancer cells sensitive (A2780) and resistant (A2780-DX3) to topoisomerase II inhibitors. 30-min drug treatments produced SCEs, CAs and DSBs in sensitive cells, doxorubicin being more potent than etoposide at equimolar concentrations. The same treatments of resistant (A2780-DX3) cells did not produce chromosomal damage (SCEs, CAs, DSBs) and no cytotoxicity was observed. A plot of cytotoxicity versus SCEs indicated a good correlation between these two parameters for topoisomerase II inhibitors and not for mytomicin C. The plot of DSBs versus SCEs also showed a very good correlation.

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Citations

Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·F VikhanskayaP Russo
May 13, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·M C AraújoC S Takahashi
Jan 5, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Nevenka KopjarIvan Milas
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Aug 16, 2011·Pharmacology & Therapeutics·Rene KizekMarie Stiborova
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Jun 18, 2002·Journal of Cellular and Molecular Medicine·C MarzanoF Bordin
Sep 16, 2006·The Journal of Biological Chemistry·Ailing ZhangLeroy F Liu

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