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Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

The EMBO Journal

Jul 6, 2000

R D Johnson, Maria Jasin

Abstract

In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms. By definition, homologous recombination requires a template with sufficient sequence identity to the damaged molecule in order to direct repair. We now show that the si...read more

Mentioned in this Paper

Sister Chromatid Exchange
Polaron
Base Excision Repair
Recombination, Genetic
Chromatids
Genotoxic Stress
Cricetus
Paper Details
References
  • References33
  • Citations270
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  • References33
  • Citations270
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DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

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Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

The EMBO Journal

Jul 6, 2000

R D Johnson, Maria Jasin

PMID: 10880452

DOI: 10.1093/emboj/19.13.3398

Abstract

In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms. By definition, homologous recombination requires a template with sufficient sequence identity to the damaged molecule in order to direct repair. We now show that the si...read more

Mentioned in this Paper

Sister Chromatid Exchange
Polaron
Base Excision Repair
Recombination, Genetic
Chromatids
Genotoxic Stress
Cricetus

Similar Papers Found In These Feeds

DNA Repair

DNA repair is critical to prevent detrimental mutations and maintain genomic stability that can otherwise lead to disease and disability. There are a number of different mechanisms of repair including base excision repair, direct repair, nucleotide excision repair and double-strand break repair. Discover the latest research on DNA repair here.

Related Papers

Paper Details
References
  • References33
  • Citations270
1234
  • References33
  • Citations270
12345...
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