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Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

The EMBO Journal

Jul 3, 2000

Rodney W Johnson, Maria Jasin

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Abstract

In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms. By definition, homologous recombination requires a template with sufficient sequence identity to the damaged molecule in order to direct repair. We now show that the si...read more

Mentioned in this Paper

Cricetus
Recombination, Genetic
Genotoxic Stress
Chromatids
Sister Chromatid Exchange
Base Excision Repair
Polaron
Paper Details
References
    • References33
    • Citations251
    • References33
    • Citations251
  • Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells

    The EMBO Journal

    Jul 3, 2000

    Rodney W Johnson, Maria Jasin

    PMID: 10880452

    DOI: 10.1093/emboj/19.13.3398

    Abstract

    In mammalian cells, repair of DNA double-strand breaks (DSBs) occurs by both homologous and non-homologous mechanisms. By definition, homologous recombination requires a template with sufficient sequence identity to the damaged molecule in order to direct repair. We now show that the si...read more

    Mentioned in this Paper

    Cricetus
    Recombination, Genetic
    Genotoxic Stress
    Chromatids
    Sister Chromatid Exchange

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    Paper Details
    References
    • References33
    • Citations251
    • References33
    • Citations251
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