Sitagliptin rescues memory deficits in Parkinsonian rats via upregulating BDNF to prevent neuron and dendritic spine loss

Neurological Research
Jing LiLan Ma

Abstract

Parkinson's disease (PD) is a neurodegenerative disease with high morbidity among adults worldwide that causes tremendous trouble to people's lives. The purpose of this study was to investigate the impact of sitagliptin on PD and its potential mechanism. First, the memory of rats in each group was evaluated with the Morris water maze (MWM) test and the passive avoidance test. Then, both brain-derived neurotrophic factor (BDNF) protein and mRNA levels were detected by ELISA and qPCR assays, respectively. Then, rapid Golgi impregnation was used to observe the density of dendritic spines in the hippocampal CA1 area. Finally, k252a, an antagonist of Trk receptors, was used to block the binding of BDNF with its receptors, and the effects of sitagliptin on PD improvement were detected. Our study showed that sitagliptin improved memory deficits in PD rats. Meanwhile, the expression level of BDNF and tyrosine hydroxylase (TH) was upregulated, and the density of dendritic spine was increased by sitagliptin administration. Moreover, K252a administration blocked the positive effects of sitagliptin on memory in PD rats. Sitagliptin rescued the memory deficits, which was achieved by upregulating BDNF to prevent neuronal death and dendritic ...Continue Reading

References

Jan 12, 2012·Neuroscience Bulletin·Ruiping Xia, Zhi-Hong Mao
Apr 10, 2012·CNS & Neurological Disorders Drug Targets·Giuseppe Di GiovanniRoberto Di Maio
Apr 10, 2012·CNS & Neurological Disorders Drug Targets·Mohd Shahnawa KhanMohd M Khan
Apr 10, 2012·CNS & Neurological Disorders Drug Targets·Robert B White, Meghan G Thomas
Apr 10, 2012·CNS & Neurological Disorders Drug Targets·Yanzhen ZhuYanjun Zeng
Jun 12, 2012·Lancet·Rory J McCrimmonBrian M Frier
Apr 25, 2013·The International Journal of Neuroscience·Limeng DaiYun Bai
Sep 26, 2013·CNS & Neurological Disorders Drug Targets·Marcelo M S LimaAnete C Ferraz
Nov 12, 2013·Neurorehabilitation and Neural Repair·Giuseppe FrazzittaCristoforo Comi
Jan 8, 2014·Neuroscience Letters·Monika BiałeckaJarosław Sławek
Jan 23, 2014·Cognitive Neuropsychiatry·Ahmed A MoustafaDoaa H Hewedi
Apr 15, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Rasool HaddadiHamdolah Sharifi
Jun 7, 2014·Frontiers in Systems Neuroscience·Atsushi Nambu, Yoshihisa Tachibana
Dec 3, 2014·Neurobiology of Aging·Nicolien M van der KolkBart P van de Warrenburg
Mar 3, 2015·Lancet Neurology·Paula S KoekkoekGeert Jan Biessels
Jul 2, 2015·Annals of the New York Academy of Sciences·Amir MoheetElizabeth R Seaquist
Jul 12, 2016·Recent Patents on Endocrine, Metabolic & Immune Drug Discovery·Mohammad R AshraghiMarios Politis
Sep 2, 2017·Movement Disorders : Official Journal of the Movement Disorder Society·Brage BrakedalCharalampos Tzoulis
Sep 21, 2017·Neuropharmacology·Dilan Athauda, Thomas Foltynie
Sep 30, 2017·Nature Reviews. Neurology·Joseph Jankovic
Oct 17, 2017·Neurology·Brit MollenhauerUNKNOWN Parkinson's Progression Marker Initiative

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Citations

Mar 21, 2019·World Journal of Diabetes·Eleni XourgiaAndreas Melidonis
Jun 8, 2019·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros
Oct 13, 2019·Current Medicinal Chemistry·Agnieszka JankowskaGrażyna Chłoń-Rzepa

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