Site alpha is crucial for two routes of IFN gamma-induced MHC class I transactivation: the ISRE-mediated route and a novel pathway involving CIITA

Immunity
S J GobinP J van den Elsen

Abstract

The constitutive and cytokine-induced levels of major histocompatibility (MHC) class I expression are tightly controlled at the transcriptional level. In this study, it is shown that the cis-acting regulatory element site alpha of the MHC class I promoter is essential for the IFN gamma-induced transactivation of MHC class I gene expression through the ISRE. Moreover, it was discovered that the class II transactivator (CIITA), which is itself under the control of the IFN gamma induction pathway, strongly transactivates MHC class I gene expression and exerts its activity through site alpha. Therefore, site alpha is a crucial regulatory element, mediating the classic route of IFN gamma induction via the ISRE as well as a novel route of MHC class I transactivation involving CIITA.

References

May 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·S J OnoL H Glimcher
Oct 10, 1991·Nature·A P KellyJ Trowsdale
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·H A BluyssenD E Levy
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Jun 29, 1995·Nature·V S SloanD M Zaller
Apr 1, 1995·The Journal of Experimental Medicine·K L WrightJ P Ting
Jan 1, 1994·Critical Reviews in Immunology·P Le Bouteiller
Feb 1, 1995·The Journal of Experimental Medicine·C H Chang, R A Flavell
Feb 1, 1993·Current Opinion in Immunology·J P Ting, A S Baldwin
Jan 1, 1996·Annual Review of Immunology·B MachW Reith
Feb 1, 1996·Current Opinion in Immunology·P J Lehner, P Cresswell
Jan 1, 1996·Current Opinion in Hematology·K Marusina, J J Monaco

❮ Previous
Next ❯

Citations

Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·M GriffioenP I Schrier
Jul 15, 1999·Journal of Cellular Biochemistry·W J DeVito, S Stone
Jan 22, 2002·International Journal of Cancer. Journal International Du Cancer·Nienke van der StoepPeter J van den Elsen
Nov 26, 2010·Cellular and Molecular Life Sciences : CMLS·Eduardo A DonadiPhilippe Moreau
Jan 22, 2004·Current Opinion in Immunology·Peter J van den ElsenNienke van der Stoep
Jun 18, 1999·Transplantation Proceedings·S MaierE H Weiss
Jun 18, 1999·Transplantation Proceedings·S J GobinP J Van den Elsen
Jul 27, 2001·Developmental and Comparative Immunology·A B AntaoV G Chinchar
Oct 11, 2003·Pharmacology & Therapeutics·Dhananjaya V Kalvakolanu
Sep 21, 2000·Journal of Reproductive Immunology·W J Magner, T B Tomasi
Oct 16, 2001·Journal of Reproductive Immunology·P J van den ElsenH E Viëtor
Aug 23, 2000·Immunology Today·B SeligerS Ferrone
Jul 17, 1998·Immunology Today·P J van den ElsenS J Gobin
Jun 1, 2002·Human Immunology·Claudine MatteUNKNOWN ZVITAMBO Study Group
Oct 24, 2002·Human Immunology·Giulio Lelio PalmisanoGiovanni Battista Ferrara
Dec 30, 1999·Microbes and Infection·P J van den Elsen, S J Gobin
Dec 30, 1999·Microbes and Infection·C H ChangT Gourley
Dec 30, 1999·Microbes and Infection·J D FontesB M Peterlin
Nov 23, 2011·Immunology and Cell Biology·Karrune V WoanAlejandro Villagra
Oct 4, 2005·Nature Reviews. Immunology·Walter ReithJean-Marc Waldburger
Feb 25, 2006·Nature Reviews. Immunology·Jenny P-Y TingHal M Hoffman
Nov 24, 2012·Nature Reviews. Immunology·Koichi S Kobayashi, Peter J van den Elsen
Apr 8, 1998·British Journal of Haematology·L AmiotB Drenou
Sep 1, 2001·Clinical and Experimental Immunology·C Le MorvanM Drouet
Jul 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Torsten B MeissnerKoichi S Kobayashi
Feb 11, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Sucharitha Balu, Pete Kaiser
Dec 27, 2005·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dhananjaya V Kalvakolanu, Sanjit K Roy
Aug 11, 2000·Molecular and Cellular Biology·J A Harton, J P Ting
Mar 13, 2001·Annual Review of Immunology·W Reith, B Mach
Mar 18, 2005·Annual Review of Immunology·Jenny P-Y Ting, Beckley K Davis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.