Site-directed non-covalent polymer-drug complexes for inflammatory bowel disease (IBD): Formulation development, characterization and pharmacological evaluation

Journal of Controlled Release : Official Journal of the Controlled Release Society
Siddharth S KesharwaniHemachand Tummala

Abstract

Inflammatory Bowel Diseases (IBD) is a debilitating condition that affects ~70,000 new people every year and has been described as "an expensive disease with no known cure". In addition, IBD increases the risk of developing colon cancer. The current therapeutics for IBD focus on the established disease where the immune dysfunction and bowel damage have already occurred but do not prevent or delay the progression. The current work describes a polymer-based anti-inflammatory technology (Ora-Curcumin-S) specifically targeted to the luminal side of the colon for preventing and/or treating IBD. Ora-Curcumin-S was prepared by molecular complexation of curcumin with a hydrophilic polymer Eudragit® S100 using co-precipitation method. Curcumin interacted with the polymer non-covalently and existed in an amorphous state as demonstrated by various physicochemical techniques. Ora-Curcumin-S is a polymer-drug complex, which is different than solid dispersions in that the interactions are retained even after dissolving in aqueous buffers. Ora-Curcumin-S was >1000 times water soluble than curcumin and importantly, the enhanced solubility was pH-dependent, which was observed only at pHs above 6.8. In addition, around 90% of Ora-Curcumin-S was ...Continue Reading

Citations

May 27, 2020·Acta Pharmacologica Sinica·Simon Van Herck, Bruno G De Geest
Mar 13, 2020·Cancer Management and Research·Yuxiu ShenHongyan Yuan
Apr 11, 2020·International Journal of Nanomedicine·Chang-Shun LiuXiao-Mei Tan
Apr 8, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Nan PanBotao Song
Dec 22, 2020·Molecular Immunology·Farzaneh FallahiHamed Mirzaei
Jun 21, 2020·Drug Discovery Today·Annemarie BroesderWouter L J Hinrichs
May 18, 2021·Acta Pharmaceutica Sinica. B·Qingqing XiaoWei He
Jul 20, 2021·Advanced Drug Delivery Reviews·Zhejie ChenYitao Wang

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A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

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