Site of ATP and phenylephrine synergistic stimulation of vasopressin release from the hypothalamo-neurohypophyseal system

Journal of Neuroendocrinology
Zhilin Song, Celia D Sladek

Abstract

ATP and norepinephrine are neurotransmitters carrying cardiovascular information to vasopressin (AVP) neurones. As shown previously, exposure of hypothalamo-neurohypophyseal system explants to ATP and phenylephrine (PE) (alpha(1)-adrenergic agonist) causes a significantly larger increase in AVP release than with either agent alone and converts the response from a transient to a sustained stimulation of AVP release. Potential mechanisms for this synergism include presynaptic stimulation of excitatory afferent input (i.e. glutamate release), postsynaptic activation of receptors on AVP neurones, modulation of stimulus-secretion coupling in the neural lobe and/or involvement of glial/neuronal interactions. The response to ATP + PE (100 microM each) was not altered in the presence of either a cocktail of ionotropic glutamate receptor antagonists (CNQX + AP5) or a nonselective metabotropic glutamate receptor antagonist [(RS)-alpha-methyl-4-carboxyphenylglycine]. Thus, it is not dependent on activation of glutamate receptors. Treatment with tetrodotoxin (3 microM) eliminated the response to ATP + PE. Because this could reflect blockade of action potentials propagated from the AVP perikarya to the nerve terminals in the neural lobe or ...Continue Reading

References

Feb 1, 1995·Journal of Neuroendocrinology·Z P ChenS L Lightman
May 1, 1996·Circulation Research·R M GrahamM T Piascik
Dec 15, 1995·The Journal of Physiology·H Hiruma, C W Bourque
Dec 1, 1996·Journal of Autonomic Pharmacology·G Lambrecht
Jun 1, 1997·Journal of Neurophysiology·C BoudabaJ G Tasker
Nov 7, 1999·Progress in Brain Research·G Burnstock
Feb 28, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sean D StockerAlan F Sved
Jul 5, 2005·Nature Neuroscience·Grant R J GordonJaideep S Bains

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Citations

Jul 25, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dayane A GomesCelia D Sladek
Nov 23, 2013·Purinergic Signalling·Geoffrey Burnstock
Oct 6, 2009·Trends in Endocrinology and Metabolism : TEM·Stanko S Stojilkovic
May 26, 2009·Experimental Neurology·Makoto KawasakiHarold Gainer
Dec 9, 2008·Autonomic Neuroscience : Basic & Clinical·Cristiane BusnardoFernando Morgan Aguiar Corrêa
Sep 28, 2013·Wiley Interdisciplinary Reviews. Membrane Transport and Signaling·Stanko S Stojilkovic, Hana Zemkova
Sep 17, 2013·Journal of Cellular Physiology·Adolfo E CuadraJosé R Lemos
Jun 20, 2006·Pharmacology & Therapeutics·Cinzia VolontéGeoffrey Burnstock
May 12, 2015·Autonomic Neuroscience : Basic & Clinical·Ivana BjelobabaStanko S Stojilkovic
Jan 28, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhilin SongCelia D Sladek
Sep 16, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhilin SongCelia D Sladek
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Jun 12, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zhilin SongWanida Stevens
Oct 7, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christopher J DavisJames M Krueger
Apr 24, 2015·Journal of Neurophysiology·Hildebrando Candido Ferreira-NetoJavier E Stern

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