PMID: 3991235Jan 1, 1985Paper

Site potential for challenge attrition in mice, rats and guinea pigs vaccinated with irradiated cercariae of Schistosoma mansoni

Parasite Immunology
D J McLarenS R Smithers

Abstract

The potential sites of attrition of a challenge population of schistosomes have been investigated in mice, rats and guinea pigs vaccinated with irradiated cercariae of Schistosoma mansoni, by the use of challenge regimens that permit sequential site elimination. Vaccinated mice showed significant immunity to a percutaneous cercarial challenge, but were only marginally resistant to an i.v. challenge with healthy lung stage worms. Vaccinated rats and guinea pigs differed from mice, in that they were able to mediate significant challenge attrition at post-skin sites. Healthy lung worms were subject to immune elimination by rats in the lungs, or perhaps en route to the liver, but not in the liver itself. In contrast, guinea pigs had the capacity to kill challenge lung worms injected into either the lungs or the liver. Interestingly, lung worms harvested by extended incubation were shown to be sub-optimal in terms of viability, since they were eliminated in significant numbers when injected i.v. into vaccinated mice. These data show that different hosts vaccinated in essentially the same manner differ in terms of their site potential for challenge attrition. It is emphasised however, that sites implicated by these experiments as hav...Continue Reading

References

Nov 1, 1977·The American Journal of Tropical Medicine and Hygiene·S R SmithersF J Ramalho-Pinto
Jan 1, 1978·The Journal of Experimental Medicine·F J Ramalho-PintoS R Smithers
Aug 1, 1984·Parasitology·D J McLaren
Feb 1, 1983·Experimental Parasitology·D A Dean
Mar 1, 1982·Parasite Immunology·D J McLaren, R J Terry
Sep 1, 1980·The American Journal of Tropical Medicine and Hygiene·S R Smithers, K L Miller

Citations

Sep 1, 1989·International Journal for Parasitology·A FlisserD J McLaren
Apr 1, 1993·International Journal for Parasitology·K P Piper, D J McLaren
Jan 15, 1987·Molecular and Biochemical Parasitology·M V Rogers, D J McLaren
Jun 1, 1987·Experimental Parasitology·S L James
Jul 1, 1989·Parasite Immunology·A FlisserD J McLaren
Oct 27, 2004·Molecular and Biochemical Parasitology·Rachel S CurwenR A Wilson
Jan 6, 2009·The Journal of Eukaryotic Microbiology·Jitender P Dubey
Nov 1, 1987·Revista Do Instituto De Medicina Tropical De São Paulo·P M CoelhoC A Tavares

Related Concepts

Cavia porcellus
Active Immune Response
Liver
Lung
Mice, Inbred CBA
Mice, Inbred C57BL
Schistosoma mansoni
Katayama Fever
Skin
Vaccination

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