Site-selective multi-porphyrin attachment enables the formation of a next-generation antibody-based photodynamic therapeutic

Chemical Communications : Chem Comm
Antoine MaruaniVijay Chudasama

Abstract

Herein we present a significant step towards next-generation antibody-based photodynamic therapeutics. Site-selective modification of a clinically relevant monoclonal antibody, with a serum-stable linker bearing a strained alkyne, allows for the controlled Cu-free "click" assembly of an in vitro active antibody-based PDT agent using a water soluble azide porpyhrin.

References

Jan 7, 2004·Advanced Drug Delivery Reviews·G A M S van DongenM B Vrouenraets
Jun 24, 2006·Nature Reviews. Cancer·Ana P CastanoMichael R Hamblin
Jul 6, 2007·The New England Journal of Medicine·Clifford A Hudis
Jul 22, 2008·Nature Biotechnology·Jagath R JunutulaWilliam Mallet
Sep 23, 2009·Bioconjugate Chemistry·Laurent Ducry, Bernhard Stump
Jun 1, 2010·Photodiagnosis and Photodynamic Therapy·Ron R Allison, Claudio H Sibata
Sep 2, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jagath R JunutulaMark X Sliwkowski
Mar 17, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Aaron J BullousRoss W Boyle
May 7, 2011·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Andrzej M Bugaj
Jul 9, 2011·Chemical Communications : Chem Comm·Vijay ChudasamaStephen Caddick
Oct 2, 2012·The New England Journal of Medicine·Sunil VermaUNKNOWN EMILIA Study Group
Dec 21, 2012·Chemical Biology & Drug Design·John A FlygarePaul Aristoff
May 1, 2013·Nature Reviews. Drug Discovery·Asher Mullard
Aug 10, 2013·Chemical Communications : Chem Comm·Lourdes CastañedaStephen Caddick
Aug 12, 2014·Organic & Biomolecular Chemistry·Felix F SchumacherStephen Caddick
Jan 23, 2015·Organic & Biomolecular Chemistry·Patricia M R PereiraJoão P C Tomé
Mar 5, 2015·Organic & Biomolecular Chemistry·Rachel E MorganStephen Caddick
Apr 1, 2015·Nature Communications·Antoine MaruaniStephen Caddick
Jun 9, 2015·Chemical Communications : Chem Comm·João P M NunesVijay Chudasama
Jun 26, 2015·Organic & Biomolecular Chemistry·Mark E B SmithVijay Chudasama
Jul 17, 2015·Current Medicinal Chemistry·Samir AcherarRegis Vanderesse

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Citations

Feb 6, 2016·International Journal of Molecular Sciences·Houzong YaoGe Zhang
Jan 23, 2016·Nature Chemistry·Vijay ChudasamaStephen Caddick
Dec 15, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Kalliopi LadomenouAthanassios G Coutsolelos
Jun 10, 2016·Organic & Biomolecular Chemistry·Antoine MaruaniVijay Chudasama
Aug 1, 2016·Photodiagnosis and Photodynamic Therapy·Derya TopkayaFabienne Dumoulin
Aug 10, 2016·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·H PyeL B Lovat
Oct 26, 2016·Chemistry : a European Journal·Seah Ling KuanTanja Weil
Feb 20, 2018·Chemistry : a European Journal·Kenji Watanabe, Takashi Ohshima
Aug 16, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·B Habermeyer, R Guilard
Aug 29, 2018·Chemical Society Reviews·Verónica Almeida-MarreroAndrés de la Escosura
Jan 17, 2019·Organic & Biomolecular Chemistry·Sara R G FernandesJoão P C Tomé
Jan 3, 2020·Chemical Communications : Chem Comm·Marcos FernándezVijay Chudasama
Jan 1, 2016·Chemical Science·Maximillian T W LeeVijay Chudasama
Apr 9, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ana R L AraújoJosé A S Cavaleiro
Feb 26, 2020·Bioconjugate Chemistry·Antoine MaruaniVijay Chudasama
Feb 16, 2019·Bioconjugate Chemistry·Jordon Sandland, Ross W Boyle

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