Site-specific chemical modification of peptide and protein by thiazolidinediones

Organic Letters
Peng WangZheng Yin

Abstract

A direct aldol reaction employing 2,4-thiazolidinediones as nucleophilic donors was performed to modify peptides and protein under mild conditions. Various functional groups could be readily introduced into protein without conformation change.

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Citations

Dec 28, 2016·Bioconjugate Chemistry·Xiaobao BiChuan-Fa Liu
Jul 7, 2016·Organic & Biomolecular Chemistry·Richard J Spears, Martin A Fascione
Mar 3, 2018·Chemical Communications : Chem Comm·Shengjun FuZheng Yin
Nov 10, 2015·Organic & Biomolecular Chemistry·Jie ZhangJian-Feng Chen
Jan 18, 2019·Angewandte Chemie·Sebastian PomplunFrank Bergmann
Apr 18, 2019·Organic & Biomolecular Chemistry·Longhuai ChengZhen Xi
Nov 28, 2019·Angewandte Chemie·Monika RajZilma Muneeswaran

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