PMID: 7538484May 1, 1995Paper

Site-specific comparison of p53 immunostaining in squamous cell carcinomas

Human Pathology
L K CoulterV A Tron

Abstract

The p53 tumor suppressor gene is believed to be the most commonly mutated gene in human cancer. p53 is thought to function as a negative regulator of the cell cycle, arresting cells in the G1 phase. This study examined the effects of different mutagenic environments on the incidence of p53 overexpression in squamous cell carcinomas (SCCs) from sun exposed and non-sun exposed squamous epithelium. An immunohistochemical analysis was undertaken in an attempt to assay SSC for p53 overexpression, an indirect measure of missense mutant p53. Positive nuclear staining for p53 was observed in 14 of 21 sun exposed SCCs, two of 19 vulvar/perianal SCCs, and 15 of 20 oral cavity SCCs. The number of positive anogenital tumors was low compared with that of both sun exposed (chi-squared, 1 df, P = .0004) and oral (chi-squared, 1 df, P < .0001) sites. It was concluded that p53 protein accumulation is common in sun-exposed cutaneous SCC and oral SCC compared with anogenital SCC, and thus it is hypothesized that the nature of the mutagenic environment in which SCC develops directly affects the incidence of immunohistochemically detectable p53-positive cells.

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Citations

Sep 18, 2007·Journal of the American Academy of Dermatology·Aviv BarzilaiMonika Huszar
Aug 22, 2006·Journal of Cutaneous Pathology·Dalva Regina Neto PimentelLuc Weckx
Jun 5, 2003·Clinical and Experimental Immunology·A P B Black, G S Ogg
Sep 16, 1999·International Journal of Radiation Oncology, Biology, Physics·C S WongB J Cummings
Mar 16, 2000·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·A F LogulloA J Simpson
Jul 24, 1998·Journal of Cutaneous Medicine and Surgery·V A TronG Li

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