Site-specific effects of intracranial estradiol administration on recurrent insulin-induced hypoglycemia in the ovariectomized female rat

Neuroendocrinology
T Prashant Nedungadi, Karen P Briski

Abstract

Clinical and experimental studies reveal gender differences in susceptibility to dampening effects of precedent hypoglycemia on recurrent insulin-induced hypoglycemia (RIIH). Recent studies implicate the ovarian steroid, estradiol, in the regulation of RIIH, since systemic replacement of this hormone at basal estrous cycle levels maintains glucose profiles during serial insulin dosing and prevents RIIH-associated reductions in neuronal activation in key metabolic structures in the ovariectomized female rat brain. The present study investigated the hypothesis that these effects are achieved, in part, by estrogenic action within the central nervous system, including glucoregulatory structures characterized by high estrogen receptor (ER) expression. Initial experiments evaluated the impact of global intracranial administration of estradiol on RIIH. Ovariectomized rats were treated by continuous infusion of graded doses of 17β-estradiol-3-benzoate (EB) or vehicle into the lateral ventricle (LV), and injected subcutaneously with 1 or 4 doses of the intermediate-release insulin, Humulin N (HN), 1 dose per day. Animals infused with 5 or 10 µg EB/day exhibited uniform glycemic responses to 1 versus 4 doses of insulin, whereas rescue fr...Continue Reading

References

Mar 1, 1979·Physiology & Behavior·G N Wade, J M Gray
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·G N Wade, J E Schneider
Nov 1, 1991·The Journal of Clinical Endocrinology and Metabolism·M R Davis, H Shamoon
Sep 1, 1986·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·J Knudtzon
Feb 1, 1986·The American Journal of Physiology·P M Best, M Fill
Jan 1, 1986·Annals of the New York Academy of Sciences·G N Wade
Oct 1, 1993·Frontiers in Neuroendocrinology·M F DallmanM Smith
Dec 5, 1997·The Journal of Comparative Neurology·P J ShughrueI Merchenthaler
Apr 4, 1998·Brain Research. Molecular Brain Research·M OsterlundY L Hurd
May 30, 1998·Journal of Neurophysiology·I A Silver, M Erecińska
Oct 31, 2000·Nutrition·B Beck
Feb 13, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·G J Morton, M W Schwartz
Feb 13, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·R D ConeM J Low
Sep 6, 2002·Physiology & Behavior·Juli E Jones, George N Wade
Jan 30, 2004·Recent Progress in Hormone Research·Christian Bjørbaek, Barbara B Kahn
Dec 23, 2004·Journal of Neuroscience Research·Julye M AdamsBrian A Jackson
May 26, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jian QiuMartin J Kelly
Aug 1, 2006·Progress in Brain Research·M van den Top, D Spanswick

❮ Previous
Next ❯

Citations

Jul 17, 2016·Diabetes·Laura K M SteinbuschBernard Thorens
Apr 8, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Khaggeswar BheemanapallyKaren P Briski

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.