Site-specific effects of local pH changes in the substantia nigra pars reticulata on flurothyl-induced seizures

Brain Research
Libor VelísekSolomon L Moshé

Abstract

Local cerebral changes of acid-base balance may interfere with neuronal communication. Acidosis enhances and alkalosis suppresses GABAA receptor neurotransmission while there are opposite effects on NMDA receptor transmission. In this study, we determined site-specific effects of acidified solutions of Na-HEPES-artificial cerebrospinal fluid infused into the anterior or posterior area of the substantia nigra pars reticulata (SNR) in rats. Two levels of pH were compared: 6.7 and 7.4. Rats were challenged with flurothyl and the threshold for clonic and tonic-clonic seizures was determined. In the anterior SNR, there were no differences between the effects of the solution with pH 6.7 and 7.4 on flurothyl seizures. In contrast in the posterior SNR, microinfusions with pH 6.7 had proconvulsant effects. The results suggest that local pH changes may have site-specific effects on seizure susceptibility in vivo.

References

Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C M TangM Morad
Mar 1, 1994·Progress in Neurobiology·K Kaila
Nov 28, 1994·Brain Research·S L MoshéE F Sperber
May 1, 1997·Bulletin of Mathematical Biology·P LánskýL Velísek

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Citations

Apr 5, 2000·European Journal of Pharmacology·M BuemiF Tomasello
Aug 11, 2000·European Journal of Pharmacology·G CalapaiM Buemi
Sep 25, 2004·Medicinal Research Reviews·Michele BuemiGiovanni Grasso
Mar 18, 2003·Journal of Neuropathology and Experimental Neurology·M BuemiN Frisina
Sep 25, 2003·Physiological Reviews·Mitchell Chesler

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