Sites of allergic airway smooth muscle remodeling and hyperresponsiveness are not associated in the rat

Journal of Applied Physiology
Sana SiddiquiJames G Martin

Abstract

The cause-and-effect relationship between airway smooth muscle (ASM) remodeling and airway hyperresponsiveness (AHR) following allergen challenge is not well established. Using a rat model of allergen-induced ASM remodeling we explored the relationship between the site of ASM remodeling and AHR. Brown Norway rats, sensitized and challenged (3 times at 5-day intervals) with ovalbumin, were intranasally administered 0.1 mg/kg budesonide 24 and 1 h before challenge. Airway responses to aerosolized methacholine were assessed 48 h or 1 wk after three challenges. Airways were stained and analyzed for total airway wall area, area of smooth muscle-specific α-actin, and goblet cell hyperplasia, and the constant-phase model was used to resolve the changes in respiratory system mechanics into large airway and peripheral lung responses. After three ovalbumin challenges, there was a significant increase in ASM area and in the total wall area in all sized airways as well as an increase in goblet cells in the central airways. Budesonide inhibited ASM growth and central airway goblet cell hyperplasia following ovalbumin challenges. Budesonide also inhibited small but not large airway total wall area. AHR was attributable to excessive responses...Continue Reading

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Citations

Oct 26, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sharon R BullimoreAnne-Marie Lauzon
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Apr 24, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Kimitake TsuchiyaJames G Martin

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