Sites of colonization in hospitalized patients with infections caused by extended-spectrum beta-lactamase organisms: a prospective cohort study

Antimicrobial Resistance and Infection Control
Z A KanafaniG M Matar

Abstract

The objective of this study was to determine whether patients infected with extended-spectrum beta-lactamase (ESBL)-producing organisms are colonized at multiple body sites. This was a prospective cohort study at a tertiary care center in Beirut, Lebanon. Hospitalized patients with infections caused by ESBL-producing organisms were included. Cultures were obtained from the primary site of infection as well as from other sites (skin, nasopharynx, urine, rectum). Molecular analysis was performed on isolates to determine clonal relatedness. One hundred patients were included in the study. Only 22 patients had positive cultures from sites other than the primary site of infection. The most common ESBL gene was CTX-M-15 followed by TEM-1. In 11 of 22 patients, isolates collected from the same patient were 100% genetically related, while in the remaining patients, genomic relatedness ranged from 42.9% to 97.1%. Colonization at sites other than the primary site of infection was not common among our patient population infected with ESBL-producing organisms. The dynamics of transmission of these bacterial strains should be studied in further prospective studies to determine the value of routine active surveillance and the need for expand...Continue Reading

References

Jan 28, 2005·The New England Journal of Medicine·George A Jacoby, Luisa Silvia Munoz-Price
May 27, 2005·The Journal of Antimicrobial Chemotherapy·Johann D D PitoutLaurent Poirel
Oct 15, 2005·Clinical Microbiology Reviews·David L Paterson, Robert A Bonomo
Feb 23, 2008·The Lancet Infectious Diseases·Johann D D Pitout, Kevin B Laupland
Mar 8, 2008·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S S KanjG M Matar
May 27, 2011·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abdulkader F TawfikMohamed H M Al-Agamy
Sep 1, 2015·Journal of Infection in Developing Countries·Milena DropaMaria Helena Matté
Nov 4, 2015·Acta Veterinaria Scandinavica·Johan StedtMirva Drobni
Nov 21, 2015·Jundishapur Journal of Microbiology·Hasan AfzaliMohammad Zibaei
May 5, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Styliani KaranikaEleftherios Mylonakis
Oct 6, 2016·Infection & chemotherapy·L Gayani TillekeratneChristopher W Woods

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Methods Mentioned

BETA
PCR
electrophoresis

Software Mentioned

BIONUMERCS
SPSS Statistics
Digi
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