Sites of distant metastases and overall survival in ovarian cancer: A study of 1481 patients

Gynecologic Oncology
Kui DengYan Hou

Abstract

To assess the association between patterns of distant metastases and overall survival in metastatic ovarian cancer and identify prognostic factors for site-specific distant metastases. Data was obtained from the SEER database between 2010 and 2014. Univariate and multivariate Cox proportional hazard models were used to identify variables associated with overall survival. Survival times between different groups were compared using Kaplan-Meier analysis and log-rank tests. We analyzed 1481 patients. The most common distant metastatic site was liver, followed by distant lymph nodes, lung, bone, and brain. The site of distant metastases was an independent prognostic factor for overall survival. Using liver metastases as reference, overall survival was lower for lung metastases (p = 0.0297) and higher for distant lymph node metastases (p = 0.0006). Using distant lymph nodes as reference, distant metastases to the liver (p = 0.0006), lung (p < 0.0001), brain (p = 0.0455), and bone (p = 0.0138) were all associated with worse overall survival. The number of metastatic sites did not affect overall survival. We also found that surgery and chemotherapy affected overall survival for patients with distant lymph node metastases only; age, hi...Continue Reading

Citations

Sep 29, 2018·Cancers·Laurie G HudsonAngela Wandinger-Ness
Apr 2, 2019·PLoS Computational Biology·Philip Gerlee, Mia Johansson
Sep 24, 2020·International Journal of Colorectal Disease·Mingshuang TangLihua Wang
Jul 25, 2020·Journal of Cardiothoracic Surgery·Ryu KanzakiUNKNOWN for Thoracic Surgery Study Group of Osaka University (TSSGO)
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Feb 27, 2021·Journal of Vascular and Interventional Radiology : JVIR·Eduardo A LacayoHooman Yarmohammadi
May 9, 2021·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Naziye AkPinar Saip
Jan 8, 2021·Chinese Medical Journal·Hao DengXiao-Ping Li
Dec 11, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dun-Chang Mo, Tao Ren
Dec 11, 2021·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Junzo Hamanishi

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