Sites of neocortical reorganization critical for remote spatial memory

Science
Thibault MavielBruno Bontempi

Abstract

The hippocampus is crucial for spatial memory formation, yet it does not store long-lasting memories. By combining functional brain imaging and region-specific neuronal inactivation in mice, we identified prefrontal and anterior cingulate cortices as critical for storage and retrieval of remote spatial memories [correction]. Imaging of activity-dependent genes also revealed an involvement of parietal and retrosplenial cortices during consolidation of remote memory. Long-term memory storage within some of these neocortical regions was accompanied by structural changes including synaptogenesis and laminar reorganization, concomitant with a functional disengagement of the hippocampus and posterior cingulate cortex [correction]. Thus, consolidation of spatial memory requires a time-dependent hippocampal-cortical dialogue, ultimately enabling widespread cortical networks to mediate effortful recall and use of cortically stored remote memories independently.

References

Apr 1, 1995·Current Opinion in Neurobiology·L R Squire, P Alvarez
Sep 1, 1995·Brain Research. Brain Research Reviews·H J Markowitsch
Sep 1, 1996·Biological cybernetics·R Miller
Feb 1, 1997·Trends in Neurosciences·L I Benowitz, A Routtenberg
Aug 1, 1997·Neurology·N TakahashiK Hirayama
Jun 23, 1998·Current Opinion in Neurobiology·M Moscovitch, L Nadel
Jan 15, 2000·Science·J L McGaugh
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·A RouttenbergU Namgung
Sep 14, 2000·Hippocampus·E Save, B Poucet
Mar 17, 2001·Nature Reviews. Neuroscience·H Eichenbaum
Apr 5, 2001·Brain : a Journal of Neurology·J M MurreJ R Hodges
Sep 21, 2002·Science·K L Hoffman, B L McNaughton
Oct 10, 2003·Nature·Matthew P WalkerRobert Stickgold
Jan 28, 2004·Annual Review of Psychology·Yadin Dudai

❮ Previous
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Citations

Sep 25, 2004·Hippocampus·Jerome L RekartAryeh Routtenberg
Nov 4, 2004·Hippocampus·Robert E ClarkLarry R Squire
Dec 6, 2005·Experimental Brain Research·Y HatadaY Rossetti
Jun 15, 2011·Brain Structure & Function·Michael LoureiroAnne Pereira de Vasconcelos
Dec 25, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Dian-Shi Wang, Beverley A Orser
Mar 5, 2013·Behavioural Brain Research·Aldis P Weible
Mar 21, 2013·Behavioural Brain Research·Estibaliz AmpueroFrancisco Javier Rubio
Jun 29, 2005·Brain Research Bulletin·Jessica D GatewoodCraig Howard Kinsley
Apr 12, 2005·Neurobiology of Learning and Memory·Grace Schenatto PereiraIván Izquierdo
Jun 8, 2013·Neurobiology of Learning and Memory·Magdalene I SchlesigerStefan Leutgeb
Jun 19, 2013·Neurobiology of Learning and Memory·Brian J Wiltgen, Kazumasa Z Tanaka
Jul 9, 2013·Neurobiology of Learning and Memory·Cynthia KatcheJorge H Medina
Aug 6, 2013·Neurobiology of Learning and Memory·Nathan Insel, Kaori Takehara-Nishiuchi
Aug 27, 2013·Neurobiology of Learning and Memory·Thomas J Gould, Prescott T Leach
Jul 7, 2011·Journal of the International Neuropsychological Society : JINS·Gordon Winocur, Morris Moscovitch
Apr 21, 2005·Behavioral Neuroscience·Kimberly M Christian, Richard F Thompson
Sep 29, 2005·Behavioral Neuroscience·Gennifer LoveKelly G Lambert
Jan 29, 2011·Nature·Dillon Y ChenCristina M Alberini
Aug 9, 2012·Nature Communications·Johannes GräffIsabelle M Mansuy
Dec 17, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark KilgoreGavin Rumbaugh
Mar 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Koji MatsuoJair C Soares
Nov 4, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sophia VinogradovEtienne de Villers-Sidani
Apr 27, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marco ContrerasFernando Torrealba
Dec 15, 2007·Nature Protocols·Nohjin KeePaul W Frankland
Feb 3, 2005·Nature Reviews. Neuroscience·Paul W Frankland, Bruno Bontempi
Jan 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Alexander G OphirSteven M Phelps
May 3, 2011·Proceedings of the National Academy of Sciences of the United States of America·Gisella VeterePaul W Frankland
Sep 29, 2011·Proceedings of the National Academy of Sciences of the United States of America·Adrien PeyracheAlain Destexhe
Feb 8, 2006·Neuroreport·Sonja BlumPramod K Dash
Jul 18, 2012·Learning & Memory·Szu-Han WangRichard G M Morris
Jan 17, 2013·Learning & Memory·Iva B ZovkicJ David Sweatt
Jun 8, 2007·Learning & Memory·Matthew R HolahanAryeh Routtenberg
Sep 13, 2007·Learning & Memory·Chi-Shing ChanRonald L Davis

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