Sivelestat attenuates postoperative pulmonary dysfunction after total arch replacement under deep hypothermia

European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
Naoto MorimotoY Okita

Abstract

Total arch replacement necessitating deep hypothermia with circulatory arrest has a greater effect on pulmonary function than other cardiac surgery using cardiopulmonary bypass (CPB). Since April 2004, 100mg of sivelestat sodium hydrate was administrated by bolus injection into pulp circuit at the initiation of CPB in every case performed total arch replacement. We investigated the hypothesis that prophylactic use of the drug attenuates post-pump pulmonary dysfunction. A retrospective analysis of 120 consecutive patients who underwent total arch replacement from August 2001 to December 2006 was conducted. Patients were divided into two groups according to the date of surgery, April 2004, when we started sivelestat administration. Group A (n=60), operated after April 2004, was administrated sivelestat at the initiation of CPB. Group B (n=60), before April 2004, was not administrated. Time courses of hemodynamic variables were evaluated until 24h after surgery and those of respiratory variables and inflammatory markers until 48 h after surgery. There were no significant differences in patient age, sex, prevalence of chronic obstructive lung disease, preoperative lung function, time of operation and CPB, minimum temperature, and a...Continue Reading

Citations

Sep 2, 2011·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Keisuke MorimotoIwao Taniguchi
Feb 22, 2014·Journal of Thermal Biology·Priyadharshanan AriyaratnamAlyn H Morice
Jun 11, 2015·Best Practice & Research. Clinical Anaesthesiology·Julie L Huffmyer, Danja S Groves
Oct 1, 2011·The Journal of Thoracic and Cardiovascular Surgery·Kenji OkadaYutaka Okita
Dec 3, 2014·The Annals of Thoracic Surgery·Shunsuke MiyaharaYutaka Okita
Dec 10, 2019·Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia·Masahiro Fujii, Ryuzo Bessho
Feb 6, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Shunsuke MiyaharaUNKNOWN Japan Cardiovascular Surgery Database Organization
Apr 25, 2020·General Thoracic and Cardiovascular Surgery·Kohei HachiroTohru Asai

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