Six Mantoux tuberculin skin tests with 1, 2, 5, 10, 20, and 50 units in a healthy male without side-effects - is skin reaction a linear function of tuberculin dose?

Cases Journal
Ioannis Dk Dimoliatis, Christos A Liaskos

Abstract

Tuberculosis remains a serious disease worldwide. Anti-tuberculosis campaigners many times face negative tuberculin skin tests after Bacille Calmette Guérin vaccination. Increasing tuberculin units might be a solution. However, is skin reaction a linear function of tuberculin dose? Are there any side-effects when higher tuberculin doses are administered? Six simultaneous Mantoux tuberculin skin tests, using 1, 2, 5, 10, 20, and 50 tuberculin units (88 altogether) of purified protein derivative RT23 per 0.1 mL were applied in a healthy male Greek 35-years-old, with known natural Mycobacterium tuberculosis primary infection since five years. Skin indurations 72 hours later were 15, 22, 23, 19, 23, and 27 mm respectively. No linear relation between tuberculin dose and skin reaction observed; skin reaction increased as tuberculin dose increased but with a decreasing rate, especially after 2 TUs, which seem correctly defined for detection of natural infection. No side-effects occurred.

References

Dec 1, 1996·Tubercle and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·M N AltetL Salleras
Sep 18, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·L Y Lao, T De Guia
Mar 27, 2001·Respiratory Medicine·H F JentoftA Gulsvik

❮ Previous
Next ❯

Citations

Sep 12, 2015·Indian Journal of Public Health·Ramar PraveenBhumesh Singh Dhadwal
Aug 5, 2017·International Journal of Mycobacteriology·Anand Bimari JanagondM Mariappan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

International Journal of Epidemiology
Ma Cecilia García-Sancho FKathryn DeRiemer
The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
M BugianiW Arossa
© 2022 Meta ULC. All rights reserved