Six-month atrophy in MTL structures is associated with subsequent memory decline in elderly controls.

NeuroImage
E A MurphyAlzheimer's Disease Neuroimaging Initiative

Abstract

Neurodegeneration precedes the onset of dementias such as Alzheimer's by several years. Recent advances in volumetric imaging allow quantification of subtle neuroanatomical change over time periods as short as six months. This study investigates whether neuroanatomical change in medial temporal lobe subregions is associated with later memory decline in elderly controls. Using high-resolution, T1-weighted magnetic resonance images acquired at baseline and six-month follow-up, change in cortical thickness and subcortical volumes was measured in 142 healthy elderly subjects (aged 59-90 years) from the ADNI cohort. Regression analysis was used to identify whether change in fourteen subregions, selected a priori, was associated with declining performance on memory tests from baseline to two-year follow-up. Percent thickness change in the right fusiform and inferior temporal cortices and expansion of the right inferior lateral ventricle were found to be significant predictors of subsequent decline on memory-specific neuropsychological measures. These results demonstrate that six-month regional neurodegeneration can be quantified in the healthy elderly and might help identify those at risk for subsequent cognitive decline.

References

Jul 10, 2003·Lancet Neurology·John AshburnerPaul M Thompson
Mar 12, 2009·Human Brain Mapping·Christine Fennema-NotestineUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 29, 2009·Alzheimer Disease and Associated Disorders·Sanja KovacevicUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 12, 2009·Neurology·C R McDonaldUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 30, 2009·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Jen-Hau ChenYen-Ching Chen
Dec 4, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anders M FjellAnders M Dale
Jan 20, 2010·NeuroImage·Liana G ApostolovaUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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Citations

Sep 6, 2011·Brain Imaging and Behavior·Elizabeth A MurphyUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 12, 2012·Brain Imaging and Behavior·Paul K CraneUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Oct 17, 2012·Brain Imaging and Behavior·Kwangsik NhoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative--ADNI
Apr 6, 2011·Psychological Bulletin·Timothy A Salthouse
May 1, 2012·Journal of Clinical and Experimental Neuropsychology·Alden L GrossRichard N Jones
Apr 15, 2011·Neurology·B C DickersonL Detoledo-Morrell
Oct 20, 2012·PloS One·Dominic HollandUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Dec 14, 2012·Cerebral Cortex·Anders M FjellUNKNOWN Alzheimer Disease Neuroimaging Initiative
Apr 7, 2012·International Journal of Alzheimer's Disease·D P DevanandGregory H Pelton
Feb 20, 2014·Progress in Neurobiology·Anders M FjellUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Aug 21, 2013·Brain Structure & Function·Debra A FleischmanDavid A Bennett
Sep 14, 2013·Trends in Cognitive Sciences·Meredith N Braskie, Paul M Thompson
Oct 28, 2010·Expert Review of Neurotherapeutics·Linda K McEvoy, James B Brewer
Dec 26, 2013·Biological Psychiatry·Meredith N Braskie, Paul M Thompson
Oct 8, 2013·Clinics in Geriatric Medicine·Noll L CampbellMalaz A Boustani
Jan 16, 2016·Human Brain Mapping·Stuart J RitchieIan J Deary
Nov 4, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 11, 2011·Medical Image Analysis·Dominic HollandUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 16, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 15, 2014·Neurobiology of Aging·Sarah K MadsenUNKNOWN Alzheimer's Disease Neuroimaging Initiative (ADNI)
Apr 16, 2013·NeuroImage·Jiayu ZhouUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Dec 19, 2012·NeuroImage·Christian K TamnesUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 19, 2011·NeuroImage·Eric WestmanUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 23, 2011·Biochimica Et Biophysica Acta·Charles D Smith
Aug 13, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jul 14, 2018·Human Brain Mapping·Anne Cecilie Sjøli BråthenKristine B Walhovd
Jan 1, 2014·Scientific Data·Julian MaclarenRoland Bammer
Jun 8, 2019·Journal of Cognitive Neuroscience·George SamraniJonas Persson
Mar 7, 2019·Frontiers in Neurology·Muhammad MunirUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 12, 2019·Human Brain Mapping·Evangeline YeeUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 26, 2021·Brain : a Journal of Neurology·Evan FletcherUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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