Six-month efficacy of the Ketogenic diet is predicted after 3months and is unrelated to clinical variables

Epilepsy & Behavior : E&B
You-Jia WuShui-Zhen Zhou

Abstract

The aim of this study was to evaluate the 6-month efficacy of a Ketogenic diet (KD) in children with drug-resistant epilepsy and to analyze the associated factors that affect the efficacy of a KD. Eighty-seven pediatric patients with drug-resistant epilepsy who followed a KD for at least 6months were included in this study. The efficacy of a KD was assessed based upon the seizure frequency, as recorded by parents and caregivers. The number of cases and the degree of efficacy in different age ranges were also considered. The effects of gender, age, seizure type, etiology, blood glucose and ketone levels, seizure frequency before the diet, and cognition on the length of time on a KD were analyzed. (1) There was no significant correlation between the length of time on a KD and efficacy (χ(2)=2.31, P=0.51). The 3-month efficacy of a KD was 51%, which did not further increase when the course was extended to 6months. (2) There was a positive correlation between increased cognition and the efficacy of a KD after 3months (γ=0.31, P=0.003). (3) The efficacy analysis of 3-month treatment with a KD revealed, with respect to seizure types, that there were 37 patients with multiple seizure phenotypes and 50 patients with a single seizure ph...Continue Reading

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Citations

Oct 21, 2016·Arquivos de neuro-psiquiatria·Letícia Pereira de Brito Sampaio
Feb 9, 2017·Cell Metabolism·Patrycja Puchalska, Peter A Crawford
Sep 3, 2020·Nutrients·Alberto VerrottiGiovanni Farello
Jan 19, 2018·Nutrition Reviews·Heather M Francis, Richard J Stevenson
Oct 23, 2019·Nutrients·Marzena Ułamek-KoziołRyszard Pluta

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