Six-month outcomes after treatment of advanced heart failure with a full magnetically levitated continuous flow left ventricular assist device: report from the ELEVATE registry

European Heart Journal
Finn GustafssonJens Garbade

Abstract

The ELEVATE registry was planned to study post-approval outcomes with HeartMate 3™ (HM3), a fully magnetically levitated continuous flow left ventricular assist device (LVAD). A total of 482 patients provided consent to participate in ELEVATE (enrolled cohort). Data collection included baseline demographics, survival, adverse events, quality of life (QOL) [EuroQoL-5 Dimensions visual analogue scale (VAS), and 6-minute walk distance (6MWD)]. An additional 58 patients were implanted with HM3 during the same period but expired or were explanted prior to consent, and only survival data were collected (anonymized cohort). We report the 6-month outcomes of the patients who received HM3 as their primary implant (n = 463) and the survival of the 540 patients in the full cohort (enrolled + anonymized). Baseline characteristics included a mean age of 55.6 ± 11.7 years, 89% male, 48% ischaemic aetiology, and 70% on inotropes. The majority of patients (66%) were bridge-to-transplantation (BTT) and 32% were INTERMACS profile 1-2. Full cohort survival at 6 months was 82 ± 2%. In the enrolled primary implant patients, there was no incidence of pump thrombosis, major bleeding was 25%, major infection 35%, and any stroke type 5%. Functional cap...Continue Reading

Associated Clinical Trials

References

Nov 29, 2013·The New England Journal of Medicine·Randall C StarlingNicholas G Smedira
Jan 15, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Samer S NajjarUNKNOWN HVAD Bridge to Transplant ADVANCE Trial Investigators
Dec 30, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Michael E NassifShane J LaRue
Nov 2, 2015·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJames B Young
Dec 17, 2015·Journal of the American College of Cardiology·Ivan NetukaJan D Schmitto
Feb 29, 2016·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·James K KirklinJenny Lannon
Oct 17, 2016·The Annals of Thoracic Surgery·Ivan NetukaUNKNOWN EU TRACE Investigators
Dec 14, 2016·The New England Journal of Medicine·Mandeep R MehraUNKNOWN MOMENTUM 3 Investigators
Feb 16, 2017·European Journal of Heart Failure·Finn Gustafsson, Joseph G Rogers
Aug 31, 2017·Circulation. Heart Failure·Juan G Duero PosadaVivek Rao
Sep 30, 2017·The Journal of Thoracic and Cardiovascular Surgery·Thomas GrügerEvgenij Potapov
Mar 13, 2018·The New England Journal of Medicine·Mandeep R MehraUNKNOWN MOMENTUM 3 Investigators
Apr 21, 2018·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Evgenij V PotapovMandeep R Mehra

❮ Previous
Next ❯

Citations

Nov 14, 2018·Expert Review of Cardiovascular Therapy·Kevin GoodwinRochus Voeller
Mar 1, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Kristin KlaeskeAnna Meyer
May 10, 2019·European Journal of Heart Failure·Andrew J S Coats
Feb 20, 2020·Journal of Cardiovascular Medicine·Marco RussoMartin Andreas
Jan 26, 2020·General Thoracic and Cardiovascular Surgery·Jesse F Veenis, Jasper J Brugts
Apr 3, 2020·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Anna NowackaMatthias Kirsch
May 18, 2019·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Evgenij V PotapovFinn Gustafsson
Jan 15, 2020·Deutsches Ärzteblatt International·Jan F GummertVolkmar Falk
Feb 9, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Dylan MarshallVeli K Topkara
Jan 13, 2021·Artificial Organs·Vikas KannojiyaPrasanta Kumar Das
Jun 30, 2021·European Journal of Heart Failure·Finn Gustafsson, Ivan Netuka
Aug 16, 2021·JACC. Heart Failure·Kiran K MirzaUNKNOWN PRO-VAD Investigators
Jun 1, 2021·The Journal of Cardiovascular Surgery·Jasmin S HankeGünes Dogan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Artificial Heart & Ventricular Assist Devices

Total artificial hearts (TAH) and ventricular assist devices (VADs) provide cardiac support for patients with end-stage heart disease and have significantly improved the survival of these patients. Discover the latest research on Artificial Heart and Ventricular Assist Devices here.